QUANTITATIVE RENAL VASCULAR CASTING IN NEPHROLOGY RESEARCH.

Vincent H. Gattone, Andrew P. Evan

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The data presented herein have shown how quantitative renal vascular casting can provide morphometric data that; a) correlates with available physiologic data and b) provides insight in the intrarenal alterations in disease processes (hypertension and renal failure described herein). The basis of this methodology is the controlled renal perfusion fixation which maintains the vasculature in its functional state. After fixation the casting material is infused into the microvessels until the kidney begins to blush with the color of the pigment added. Careful attention must also be paid to the capabilities and limitations of the scanning electron microscope to be used in the quantitation. When these steps are carefully observed, the microcorrosion vascular casting method and the scanning electron microscope can effectively be applied to collect data not otherwise available.

Original languageEnglish (US)
Pages (from-to)253-262
Number of pages10
JournalScanning electron microscopy
Issue numberpt 1
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Biophysics

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