Quantitative trait loci associated with the behavioral response of B×D recombinant inbred mice to restraint stress

A preliminary communication

B. J. Tarricone, J. N. Hingtgen, J. K. Belknap, S. R. Mitchell, John Nurnberger

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Quantitative trait loci (QTL) analysis was used to make provisional identification of loci containing genes influencing vulnerability to stress. The effect of restraint stress on openfield activity was measured in C57BL/6J and DBA/2J inbred strains of mice and in 22 B×D recombinant inbred strains of mice. QTL analyses were performed by correlating the behavioral delta scores for each group with the strain distribution pattern of 1300 markers for the B×D mice. A significant association was found between postrestraint rearings during min 5 through 8 in the open field and the Lamb2 marker on chromosome 1 (r=.718, p<.0001). Significant associations at the p<.0001 level were also found between baseline open-field rearings of control mice during min 0 through 5 and the Zp3, Ache, and Mr66-1 markers on chromosome 5, baseline open-field rearings of control mice during min 5 through 8 and the Pmv42 marker on chromosome 15, and open-field rearings of experimental mice during min 0 through 5 and the D11Ncvs61 marker on chromosome 11.

Original languageEnglish
Pages (from-to)489-495
Number of pages7
JournalBehavior Genetics
Volume25
Issue number5
DOIs
StatePublished - Sep 1995

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Quantitative Trait Loci
behavioral response
animal communication
quantitative trait loci
Communication
rearing
communication
chromosome
Inbred Strains Mice
mice
chromosomes
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 1
vulnerability
Pain
marker
gene
Genes

Keywords

  • affective disorder
  • quantitative trait loci
  • recombinant inbred mice
  • Restraint stress

ASJC Scopus subject areas

  • Psychology(all)
  • Behavioral Neuroscience
  • Genetics(clinical)
  • Genetics
  • Ecology, Evolution, Behavior and Systematics

Cite this

Quantitative trait loci associated with the behavioral response of B×D recombinant inbred mice to restraint stress : A preliminary communication. / Tarricone, B. J.; Hingtgen, J. N.; Belknap, J. K.; Mitchell, S. R.; Nurnberger, John.

In: Behavior Genetics, Vol. 25, No. 5, 09.1995, p. 489-495.

Research output: Contribution to journalArticle

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