Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii

Aaron T. Smith, Meredith R. Livingston, Antonello Mai, Patrizia Filetici, Sherry Queener, William Sullivan

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We report that quinoline derivative MC1626, first described as an inhibitor of the histone acetyltransferase (HAT) GCN5, is active against the protozoan parasite Toxoplasma gondii in vitro. However, MC1626 does not inhibit Toxoplasma GCN5 HATs or reduce HAT-mediated activity; rather, this quinoline may target the plastid organelle called the apicoplast.

Original languageEnglish
Pages (from-to)1109-1111
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number3
DOIs
StatePublished - Mar 2007

Fingerprint

Histone Acetyltransferases
Toxoplasma
Apicoplasts
Plastids
Organelles
Parasites
quinoline
human KAT2A protein
MC1626
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii. / Smith, Aaron T.; Livingston, Meredith R.; Mai, Antonello; Filetici, Patrizia; Queener, Sherry; Sullivan, William.

In: Antimicrobial Agents and Chemotherapy, Vol. 51, No. 3, 03.2007, p. 1109-1111.

Research output: Contribution to journalArticle

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