Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii

Aaron T. Smith, Meredith R. Livingston, Antonello Mai, Patrizia Filetici, Sherry F. Queener, William J. Sullivan

Research output: Contribution to journalArticle

27 Scopus citations


We report that quinoline derivative MC1626, first described as an inhibitor of the histone acetyltransferase (HAT) GCN5, is active against the protozoan parasite Toxoplasma gondii in vitro. However, MC1626 does not inhibit Toxoplasma GCN5 HATs or reduce HAT-mediated activity; rather, this quinoline may target the plastid organelle called the apicoplast.

Original languageEnglish (US)
Pages (from-to)1109-1111
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Issue number3
StatePublished - Mar 1 2007


ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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