Race and medication adherence and glycemic control: findings from an operational health information exchange.

Vivienne J. Zhu, Wanzhu Tu, David G. Marrero, Marc B. Rosenman, J. Marc Overhage

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The Central Indiana Beacon Community leads efforts for improving adherence to oral hypoglycemic agents (OHA) to achieve improvements in glycemic control for patients with type 2 diabetes. In this study, we explored how OHA adherence affected hemoglobin A1C (HbA1c) level in different racial groups. OHA adherence was measured by 6-month proportion of days covered (PDC). Of 3,976 eligible subjects, 12,874 pairs of 6-month PDC and HbA1c levels were formed between 2002 and 2008. The average HbA1c levels were 7.4% for African-Americans and 6.5% for Whites. The average 6-month PDCs were 40% for African-Americans and 50% for Whites. In mixed effect generalized linear regression analyses, OHA adherence was inversely correlated with HbA1c level for both African-Americans (-0.80, p<0.0001) and Whites (-0.53, p<0.0001). The coefficient was -0.26 (p<0.0001) for the interaction of 6-month PDC and African-Americans. Significant risk factors for OHA non-adherence were race, young age, non-commercial insurance, newly-treated status, and polypharmacy.

Original languageEnglish (US)
Pages (from-to)1649-1657
Number of pages9
JournalAMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium
Volume2011
StatePublished - 2011
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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