Racial differences in potassium homeostasis in response to differences in dietary sodium in girls

Cristina Palacios, Karin Wigertz, Berdine R. Martin, Michelle Braun, J. Howard Pratt, Munro Peacock, Connie M. Weaver

Research output: Contribution to journalArticle

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Abstract

Background: Racial differences in the renal disposition of potassium may be related to mechanisms for the greater susceptibility to hypertension in blacks than in whites. Objective: Our objective was to study the racial differences in the renin-angiotensin-aldosterone system and in potassium balance in black and white girls consuming a controlled diet that was low in potassium with 2 amounts of sodium intake (low compared with high). Design: The studies reported here were performed in 40 black and 28 white girls, aged 11-15 y, under highly controlled metabolic conditions. The studies comprised 2 sessions of 20-d metabolic balance sessions, at 2 amounts of dietary sodium intake (58 and 170 mmol · L-1 · d-1), in a crossover design and with a constant dietary potassium intake of 50 mmol · L-1 · d-1. Repeated-measures analysis of variance was used to test for racial differences in potassium output and retention by sodium intakes. Results: Thirty black and 20 white girls completed the study. Urinary potassium excretion was lower in blacks than in whites, regardless of sodium intake (P < 0.05), with no differences in fecal or sweat potassium excretion. Cumulative potassium retention was significantly higher in blacks while consuming the low sodium diet. Plasma aldosterone concentrations after upright posture were significantly lower in blacks than in whites but were similar when supine, as were urinary aldosterone excretion rates. On week 3, blood pressure, body weight, urinary volume, creatinine, and serum sodium and potassium were similar. Conclusion: The well-known racial difference in urinary potassium excretion appears to be at least in part due to greater renal retention of potassium in black girls.

Original languageEnglish
Pages (from-to)597-603
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume91
Issue number3
DOIs
StatePublished - Mar 1 2010

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Dietary Sodium
Potassium
Homeostasis
Sodium
Aldosterone
Dietary Potassium
Kidney
Sodium-Restricted Diet
Sweat
Renin-Angiotensin System
Posture
Cross-Over Studies
hydroquinone
Creatinine
Analysis of Variance
Body Weight
Diet
Blood Pressure
Hypertension

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Racial differences in potassium homeostasis in response to differences in dietary sodium in girls. / Palacios, Cristina; Wigertz, Karin; Martin, Berdine R.; Braun, Michelle; Pratt, J. Howard; Peacock, Munro; Weaver, Connie M.

In: American Journal of Clinical Nutrition, Vol. 91, No. 3, 01.03.2010, p. 597-603.

Research output: Contribution to journalArticle

Palacios, Cristina ; Wigertz, Karin ; Martin, Berdine R. ; Braun, Michelle ; Pratt, J. Howard ; Peacock, Munro ; Weaver, Connie M. / Racial differences in potassium homeostasis in response to differences in dietary sodium in girls. In: American Journal of Clinical Nutrition. 2010 ; Vol. 91, No. 3. pp. 597-603.
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