Racial Differences in the Clinical Profile, Causes, and Outcome of Chronic Pancreatitis

C. Mel Wilcox, Bimaljit S. Sandhu, Vikesh Singh, Andres Gelrud, Judah N. Abberbock, Stuart Sherman, Gregory A. Cote, Samer Al-Kaade, Michelle A. Anderson, Timothy B. Gardner, Michele D. Lewis, Christopher E. Forsmark, Nalini M. Guda, Joseph Romagnuolo, John Baillie, Stephen T. Amann, Thiruvengadam Muniraj, Gong Tang, Darwin L. Conwell, Peter A. Banks & 4 others Randall E. Brand, Adam Slivka, David Whitcomb, Dhiraj Yadav

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

OBJECTIVES: Racial differences in susceptibility and progression of pancreatitis have been reported in epidemiologic studies using administrative or retrospective data. There has been little study, however, on the clinical profile, causes, and outcome of chronic pancreatitis (CP) in black patients.METHODS: We analyzed data on black patients with CP prospectively enrolled in the multicenter North American Pancreatitis Studies from 26 US centers during the years 2000-2014. CP was defined by definitive evidence on imaging studies or histology. Information on demographics, etiology, risk factors, disease phenotype, treatment, and perceived effectiveness was obtained from responses to detailed questionnaires completed by both patients and physicians.RESULTS: Of the 1,159 patients enrolled, 248 (21%) were black. When compared with whites, blacks were significantly more likely to be male (60.9 vs. 53%), ever (88.2 vs. 71.8%), or current smokers (64.2 vs. 45.9%), or have a physician-defined alcohol etiology (77 vs. 41.9%). There was no overall difference in the duration of CP although for alcoholic CP, blacks had a longer duration of disease (8.6 vs. 6.97 years; P=0.02). Blacks were also significantly more likely to have advanced changes on pancreatic morphology (calcifications (63.3 vs. 55.2%), atrophy (43.2 vs. 34.6%), pancreatic ductal stricture or dilatation (72.6 vs. 65.5%) or common bile duct stricture (18.6 vs. 8.2%)) and function (endocrine insufficiency 39.9 vs. 30.2%). Moreover, the prevalence of any (94.7 vs. 83%), constant (62.6 vs. 51%), and severe (78.4 vs. 65.8%) pain and disability (35.1 vs. 21.4%) were significantly higher in blacks. Observed differences were in part related to variances in etiology and duration of disease. No differences in medical or endoscopic treatments were seen between races although prior cholecystectomy (31.1 vs. 19%) was more common in white patients.CONCLUSIONS: Differences were observed between blacks and whites in the underlying cause, morphologic expression, and pain characteristics of CP, which in part are explained by the underlying risk factor(s) with alcohol and tobacco being much more frequent in black patients as well as disease duration.

Original languageEnglish (US)
Pages (from-to)1488-1496
Number of pages9
JournalAmerican Journal of Gastroenterology
Volume111
Issue number10
DOIs
StatePublished - Oct 1 2016

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Chronic Pancreatitis
Pancreatitis
Pathologic Constriction
Alcohols
Alcoholic Pancreatitis
Physicians
Pain
Common Bile Duct
Cholecystectomy
Atrophy
Tobacco
Epidemiologic Studies
Dilatation
Histology
Demography
Phenotype

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Wilcox, C. M., Sandhu, B. S., Singh, V., Gelrud, A., Abberbock, J. N., Sherman, S., ... Yadav, D. (2016). Racial Differences in the Clinical Profile, Causes, and Outcome of Chronic Pancreatitis. American Journal of Gastroenterology, 111(10), 1488-1496. https://doi.org/10.1038/ajg.2016.316

Racial Differences in the Clinical Profile, Causes, and Outcome of Chronic Pancreatitis. / Wilcox, C. Mel; Sandhu, Bimaljit S.; Singh, Vikesh; Gelrud, Andres; Abberbock, Judah N.; Sherman, Stuart; Cote, Gregory A.; Al-Kaade, Samer; Anderson, Michelle A.; Gardner, Timothy B.; Lewis, Michele D.; Forsmark, Christopher E.; Guda, Nalini M.; Romagnuolo, Joseph; Baillie, John; Amann, Stephen T.; Muniraj, Thiruvengadam; Tang, Gong; Conwell, Darwin L.; Banks, Peter A.; Brand, Randall E.; Slivka, Adam; Whitcomb, David; Yadav, Dhiraj.

In: American Journal of Gastroenterology, Vol. 111, No. 10, 01.10.2016, p. 1488-1496.

Research output: Contribution to journalArticle

Wilcox, CM, Sandhu, BS, Singh, V, Gelrud, A, Abberbock, JN, Sherman, S, Cote, GA, Al-Kaade, S, Anderson, MA, Gardner, TB, Lewis, MD, Forsmark, CE, Guda, NM, Romagnuolo, J, Baillie, J, Amann, ST, Muniraj, T, Tang, G, Conwell, DL, Banks, PA, Brand, RE, Slivka, A, Whitcomb, D & Yadav, D 2016, 'Racial Differences in the Clinical Profile, Causes, and Outcome of Chronic Pancreatitis', American Journal of Gastroenterology, vol. 111, no. 10, pp. 1488-1496. https://doi.org/10.1038/ajg.2016.316
Wilcox, C. Mel ; Sandhu, Bimaljit S. ; Singh, Vikesh ; Gelrud, Andres ; Abberbock, Judah N. ; Sherman, Stuart ; Cote, Gregory A. ; Al-Kaade, Samer ; Anderson, Michelle A. ; Gardner, Timothy B. ; Lewis, Michele D. ; Forsmark, Christopher E. ; Guda, Nalini M. ; Romagnuolo, Joseph ; Baillie, John ; Amann, Stephen T. ; Muniraj, Thiruvengadam ; Tang, Gong ; Conwell, Darwin L. ; Banks, Peter A. ; Brand, Randall E. ; Slivka, Adam ; Whitcomb, David ; Yadav, Dhiraj. / Racial Differences in the Clinical Profile, Causes, and Outcome of Chronic Pancreatitis. In: American Journal of Gastroenterology. 2016 ; Vol. 111, No. 10. pp. 1488-1496.
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T1 - Racial Differences in the Clinical Profile, Causes, and Outcome of Chronic Pancreatitis

AU - Wilcox, C. Mel

AU - Sandhu, Bimaljit S.

AU - Singh, Vikesh

AU - Gelrud, Andres

AU - Abberbock, Judah N.

AU - Sherman, Stuart

AU - Cote, Gregory A.

AU - Al-Kaade, Samer

AU - Anderson, Michelle A.

AU - Gardner, Timothy B.

AU - Lewis, Michele D.

AU - Forsmark, Christopher E.

AU - Guda, Nalini M.

AU - Romagnuolo, Joseph

AU - Baillie, John

AU - Amann, Stephen T.

AU - Muniraj, Thiruvengadam

AU - Tang, Gong

AU - Conwell, Darwin L.

AU - Banks, Peter A.

AU - Brand, Randall E.

AU - Slivka, Adam

AU - Whitcomb, David

AU - Yadav, Dhiraj

PY - 2016/10/1

Y1 - 2016/10/1

N2 - OBJECTIVES: Racial differences in susceptibility and progression of pancreatitis have been reported in epidemiologic studies using administrative or retrospective data. There has been little study, however, on the clinical profile, causes, and outcome of chronic pancreatitis (CP) in black patients.METHODS: We analyzed data on black patients with CP prospectively enrolled in the multicenter North American Pancreatitis Studies from 26 US centers during the years 2000-2014. CP was defined by definitive evidence on imaging studies or histology. Information on demographics, etiology, risk factors, disease phenotype, treatment, and perceived effectiveness was obtained from responses to detailed questionnaires completed by both patients and physicians.RESULTS: Of the 1,159 patients enrolled, 248 (21%) were black. When compared with whites, blacks were significantly more likely to be male (60.9 vs. 53%), ever (88.2 vs. 71.8%), or current smokers (64.2 vs. 45.9%), or have a physician-defined alcohol etiology (77 vs. 41.9%). There was no overall difference in the duration of CP although for alcoholic CP, blacks had a longer duration of disease (8.6 vs. 6.97 years; P=0.02). Blacks were also significantly more likely to have advanced changes on pancreatic morphology (calcifications (63.3 vs. 55.2%), atrophy (43.2 vs. 34.6%), pancreatic ductal stricture or dilatation (72.6 vs. 65.5%) or common bile duct stricture (18.6 vs. 8.2%)) and function (endocrine insufficiency 39.9 vs. 30.2%). Moreover, the prevalence of any (94.7 vs. 83%), constant (62.6 vs. 51%), and severe (78.4 vs. 65.8%) pain and disability (35.1 vs. 21.4%) were significantly higher in blacks. Observed differences were in part related to variances in etiology and duration of disease. No differences in medical or endoscopic treatments were seen between races although prior cholecystectomy (31.1 vs. 19%) was more common in white patients.CONCLUSIONS: Differences were observed between blacks and whites in the underlying cause, morphologic expression, and pain characteristics of CP, which in part are explained by the underlying risk factor(s) with alcohol and tobacco being much more frequent in black patients as well as disease duration.

AB - OBJECTIVES: Racial differences in susceptibility and progression of pancreatitis have been reported in epidemiologic studies using administrative or retrospective data. There has been little study, however, on the clinical profile, causes, and outcome of chronic pancreatitis (CP) in black patients.METHODS: We analyzed data on black patients with CP prospectively enrolled in the multicenter North American Pancreatitis Studies from 26 US centers during the years 2000-2014. CP was defined by definitive evidence on imaging studies or histology. Information on demographics, etiology, risk factors, disease phenotype, treatment, and perceived effectiveness was obtained from responses to detailed questionnaires completed by both patients and physicians.RESULTS: Of the 1,159 patients enrolled, 248 (21%) were black. When compared with whites, blacks were significantly more likely to be male (60.9 vs. 53%), ever (88.2 vs. 71.8%), or current smokers (64.2 vs. 45.9%), or have a physician-defined alcohol etiology (77 vs. 41.9%). There was no overall difference in the duration of CP although for alcoholic CP, blacks had a longer duration of disease (8.6 vs. 6.97 years; P=0.02). Blacks were also significantly more likely to have advanced changes on pancreatic morphology (calcifications (63.3 vs. 55.2%), atrophy (43.2 vs. 34.6%), pancreatic ductal stricture or dilatation (72.6 vs. 65.5%) or common bile duct stricture (18.6 vs. 8.2%)) and function (endocrine insufficiency 39.9 vs. 30.2%). Moreover, the prevalence of any (94.7 vs. 83%), constant (62.6 vs. 51%), and severe (78.4 vs. 65.8%) pain and disability (35.1 vs. 21.4%) were significantly higher in blacks. Observed differences were in part related to variances in etiology and duration of disease. No differences in medical or endoscopic treatments were seen between races although prior cholecystectomy (31.1 vs. 19%) was more common in white patients.CONCLUSIONS: Differences were observed between blacks and whites in the underlying cause, morphologic expression, and pain characteristics of CP, which in part are explained by the underlying risk factor(s) with alcohol and tobacco being much more frequent in black patients as well as disease duration.

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