Racial/ethnic differences in sex hormone levels among postmenopausal women in the diabetes prevention program

Catherine Kim, Sherita Hill Golden, Kieren Mather, Gail A. Laughlin, Shengchun Kong, Bin Nan, Elizabeth Barrett-Connor, John F. Randolph

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Context: Sex hormones may differ by race/ethnicity in postmenopausal women. Whether racial/ethnic differences also exist among those who are overweight and glucose intolerant is not clear. Objectives:The objective of the study was to compare sex hormones by race/ethnicity [non-Hispanic white (NHW), Hispanic, African-American (AA)] in overweight, glucose-intolerant, postmenopausal women. Design: This was a secondary analysis of a randomized controlled trial. Participants: Participants included postmenopausal glucose- intolerantwomenparticipating in the Diabetes Prevention Program. Interventions: Interventions included intensive lifestyle modification (consisting of diet and physical activity) or metformin 850 mg twice a day vs. placebo. Main Outcome Measures: Baseline levels and 1-yr intervention-related changes in SHBG, total and bioavailable estradiol (E2), total and bioavailable testosterone, and dehydroepiandrosterone were measured. Results: At baseline, among women not using estrogen (n = 370), NHW had higher total and bioavailable E2 and testosterone levels than Hispanics independent of age, type of menopause, waist circumference, alcohol intake, and current smoking. NHW also had higher levels of bioavailable E2 and lower levels of SHBG than AA. At baseline, among estrogen users (n = 310), NHW had higher total and bioavailable E2 than Hispanics and higher levels of SHBG than AA after adjustment. At 1 yr, among women not using estrogen, NHW had larger declines in total E2 and bioavailable E2 levels than AA after adjustment for the above covariates, changes in waist circumference, and randomization arm. At 1 yr, among estrogen users, sex hormone changes did not differ by race/ethnicity. Conclusions: Among postmenopausal women, there were significant race/ethnicity differences in baseline sex hormones and changes in sex hormones.

Original languageEnglish
Pages (from-to)4051-4060
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number11
DOIs
StatePublished - Nov 2012

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Gonadal Steroid Hormones
Medical problems
African Americans
Estrogens
Hispanic Americans
Waist Circumference
Glucose
Testosterone
Diet Therapy
Social Adjustment
Dehydroepiandrosterone
Metformin
Nutrition
Random Allocation
Menopause
Life Style
Estradiol
Randomized Controlled Trials
Smoking
Placebos

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Racial/ethnic differences in sex hormone levels among postmenopausal women in the diabetes prevention program. / Kim, Catherine; Golden, Sherita Hill; Mather, Kieren; Laughlin, Gail A.; Kong, Shengchun; Nan, Bin; Barrett-Connor, Elizabeth; Randolph, John F.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 97, No. 11, 11.2012, p. 4051-4060.

Research output: Contribution to journalArticle

Kim, Catherine ; Golden, Sherita Hill ; Mather, Kieren ; Laughlin, Gail A. ; Kong, Shengchun ; Nan, Bin ; Barrett-Connor, Elizabeth ; Randolph, John F. / Racial/ethnic differences in sex hormone levels among postmenopausal women in the diabetes prevention program. In: Journal of Clinical Endocrinology and Metabolism. 2012 ; Vol. 97, No. 11. pp. 4051-4060.
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