Radiation-induced adult medulloblastoma: A two-case report and review of the literature

Michael D. Chan, Albert Attia, Stephen B. Tatter, Glenn Lesser, Michael E. Zapadka, Ryan T. Mott, Annette Carter, Kevin P. McMullen, Edward G. Shaw, Thomas E. Ellis

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Radiation-induced medulloblastoma is an exceedingly rare phenomenon for which treatment standards have not been established. The literature suggests that these tumors are high grade with aggressive behavior. We report two cases of radiation-induced medulloblastoma which have been treated with full dose re-irradiation with curative intent. In both cases, treatment toxicity and tumor progression proved to be insurmountable obstacles. Further reports are necessary in order to fully characterize this clinical entity so that more effective therapies may be sought.

Original languageEnglish (US)
Pages (from-to)745-749
Number of pages5
JournalJournal of Neuro-Oncology
Volume103
Issue number3
DOIs
StatePublished - Jul 2011

Keywords

  • Medulloblastoma
  • Radiation-induced malignancy
  • Re-irradiation

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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    Chan, M. D., Attia, A., Tatter, S. B., Lesser, G., Zapadka, M. E., Mott, R. T., Carter, A., McMullen, K. P., Shaw, E. G., & Ellis, T. E. (2011). Radiation-induced adult medulloblastoma: A two-case report and review of the literature. Journal of Neuro-Oncology, 103(3), 745-749. https://doi.org/10.1007/s11060-010-0426-z