Radiation-induced bystander effect: Activation of signaling molecules in K562 erythroleukemia cells

Anirban Kumar Mitra, Malini Krishna

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Gap junction independent signaling mechanism was investigated using K562 human erythroleukemia cells. They were exposed to 2, 5, or 10 Gy of 60Co γ irradiation, the medium isolated 20 min post-irradiation and added to fresh cells. Evidence of radiation-induced bystander effect was observed wherein there was activation of p21, nuclear factor-κB (NF-κB), Bax, Bcl-2 and cleavage of poly(ADP-ribose) polymerase in bystander cells. The study implicates the involvement of signaling molecules released into the medium and factors like stable free radicals that are generated in the surrounding medium. The response elicited appears to be primarily via NF-κB and p21 activation.

Original languageEnglish (US)
Pages (from-to)991-997
Number of pages7
JournalJournal of Cellular Biochemistry
Volume100
Issue number4
DOIs
StatePublished - Mar 1 2007
Externally publishedYes

Keywords

  • Bystander
  • Nuclear factor-κB and p21
  • Radiation
  • Signaling

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Radiation-induced bystander effect: Activation of signaling molecules in K562 erythroleukemia cells'. Together they form a unique fingerprint.

Cite this