Radiation-induced intracranial malignant gliomas

S. Shapiro, J. Mealey, C. Sartorius

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations


The authors present seven cases of malignant gliomas that occurred after radiation therapy administered for diseases different from the subsequent glial tumor. Included among these seven are three patients who were treated with interstitial brachytherapy. Previously reported cases of radiation-induced glioma are reviewed and analyzed for common characteristics. Children receiving central nervous system irradiation appear particularly susceptible to induction of malignant gliomas by radiation. Interstitial brachytherapy may be used successfully instead of external beam radiotherapy in previously irradiated, tumor-free brain, and thus may reduce the risk of radiation necrosis.

Original languageEnglish (US)
Pages (from-to)77-82
Number of pages6
JournalJournal of neurosurgery
Issue number1
StatePublished - 1989

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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