Radiation nephritis following total-body irradiation and cyclophosphamide in preparation for bone marrow transplantation

Jerry Bergstein, Sharon P. Andreoli, Arthur J. Provisor, Moonahm Yum

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Abstract

Two children prepared for bone marrow transplantation with total-body irradiation and cyclophospha mide developed hypertension, microscopic hematuria, proteinuria, diminished renal function, and anemia six months after transplantation. Light microscopy of the kidneys revealed mesangial expansion, glomerular capillary wall thickening, and lumenal thrombosis. Electron microscopy demonstrated widening of the subendothelial space due to the deposition of amorphous fluffy material. In one patient, immunofluorescence micros copy revealed glomerular capillary wall deposition of fibrin and immunoglobulins. The clinical and histologic findings support the diagnosis of radiation nephritis. Patients prepared for bone marrow transplantation with total-body irradiation and cyclophosphomide should be followed closely after transplantation for the development of hypertension, proteinuria, and renal in sufficiency.

Original languageEnglish (US)
Pages (from-to)63-66
Number of pages4
JournalTransplantation
Volume41
Issue number1
DOIs
StatePublished - Jan 1986

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ASJC Scopus subject areas

  • Transplantation

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