Radiation therapy alone or in combination with surgery in the treatment of carcinoma of the esophagus

Mark Langer, N. C. Choi, E. Orlow, H. Grillo, E. W. Wilkins

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The role of radiation in the treatment of squamous cell carcinoma of the esophagus was examined in a review of 74 patients treated with curative intent between 1974 and 1981. Aspects studied included the pattern of failure, the use of radiation as a surgical adjuvant, achievement of palliation, and the presence of technical or clinical factors predicting for a better outcome. The group was divided into 9 patients irradiated after esophageal resection, 14 patients irradiated before resection, and 51 patients treated with radiation and no resection. Median and 2-year survival rates among 51 patients treated by radiation without esophagectomy were 8.8 months and 11%, whereas they were 9.7 months and 0% in patients treated by radiation followed by resection, and 9.5 months and 28% in patients undergoing resection followed by radiation. Local failures were suffered in 28/51 patients treated without esophagectomy with rates of 2/4, 7/10, 7/15, and 5/10 after 50-55 Gy, 55-60 Gy, 60-65 Gy, and 65-69 Gy, respectively. Although prognosis for patients presenting with unresectable disease remains poor, a somewhat better outcome may be expected in patients treated with postoperative radiation after potentially unfavorable resections. Other predictors include sex and disease stage.

Original languageEnglish (US)
Pages (from-to)1208-1213
Number of pages6
JournalCancer
Volume58
Issue number6
StatePublished - 1986
Externally publishedYes

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Esophagus
Radiotherapy
Carcinoma
Radiation
Therapeutics
Esophagectomy
Squamous Cell Carcinoma
Survival Rate

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Langer, M., Choi, N. C., Orlow, E., Grillo, H., & Wilkins, E. W. (1986). Radiation therapy alone or in combination with surgery in the treatment of carcinoma of the esophagus. Cancer, 58(6), 1208-1213.

Radiation therapy alone or in combination with surgery in the treatment of carcinoma of the esophagus. / Langer, Mark; Choi, N. C.; Orlow, E.; Grillo, H.; Wilkins, E. W.

In: Cancer, Vol. 58, No. 6, 1986, p. 1208-1213.

Research output: Contribution to journalArticle

Langer, M, Choi, NC, Orlow, E, Grillo, H & Wilkins, EW 1986, 'Radiation therapy alone or in combination with surgery in the treatment of carcinoma of the esophagus', Cancer, vol. 58, no. 6, pp. 1208-1213.
Langer, Mark ; Choi, N. C. ; Orlow, E. ; Grillo, H. ; Wilkins, E. W. / Radiation therapy alone or in combination with surgery in the treatment of carcinoma of the esophagus. In: Cancer. 1986 ; Vol. 58, No. 6. pp. 1208-1213.
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