Radical prostatectomy for prostatic adenocarcinoma: A matched comparison of open retropubic and robot-assisted techniques

Amy Krambeck, David S. DiMarco, Laureano J. Rangel, Eric J. Bergstralh, Robert P. Myers, Michael L. Blute, Matthew T. Gettman

Research output: Contribution to journalArticle

207 Citations (Scopus)

Abstract

OBJECTIVE: To assess the perioperative complications and early oncological results in a comparative study matching open radical retropubic (RRP) and robot-assisted radical prostatectomy (RARP) groups. PATIENTS AND METHODS: From August 2002 to December 2005 we identified 294 patients undergoing RARP for clinically localized prostate cancer. A comparison RRP group of 588 patients from the same period was matched 2:1 for surgical year, age, preoperative prostate-specific antigen level, clinical stage and biopsy Gleason grade. Perioperative complications were compared. Patients completed a standardized quality-of-life questionnaire. Pathological features were assessed and Kaplan-Meier estimates of biochemical progression-free survival (PFS) were compared. RESULTS: There was no significant difference in overall perioperative complications between the RARP and RRP groups (8.0% vs 4.8%, P = 0.064). Wound herniation was more common after RARP (1.0% vs none, P = 0.038), and development of bladder neck contracture was more common after RRP (1.2% vs 4.6%; P < 0.018). The hospital stay was less after RARP (29.3% vs 19.4%, P = 0.004, for a stay of 1 day). At the 1-year follow-up there was no significant difference in continence (RARP 91.8%, RRP 93.7%, P = 0.344) or potency (RARP 70.0%, RRP 62.8%, P = 0.081) rates. The biochemical PFS was no different between treatments at 3 years (RARP 92.4%, RRP 92.2%; P = 0.69). CONCLUSION: There was no significant difference in overall early complication, long-term continence or potency rates between the RARP and RRP techniques. Furthermore, early oncological outcomes were similar, with equivalent margin positivity and PFS between the groups.

Original languageEnglish (US)
Pages (from-to)448-453
Number of pages6
JournalBJU International
Volume103
Issue number4
DOIs
StatePublished - Feb 2009
Externally publishedYes

Fingerprint

Prostatectomy
Adenocarcinoma
Disease-Free Survival
Kaplan-Meier Estimate
Contracture
Prostate-Specific Antigen
Length of Stay
Prostatic Neoplasms
Urinary Bladder
Quality of Life
Biopsy
Wounds and Injuries

Keywords

  • Laparoscopy
  • Prostate
  • Prostatic neoplasms
  • Robotics
  • Surgery

ASJC Scopus subject areas

  • Urology

Cite this

Radical prostatectomy for prostatic adenocarcinoma : A matched comparison of open retropubic and robot-assisted techniques. / Krambeck, Amy; DiMarco, David S.; Rangel, Laureano J.; Bergstralh, Eric J.; Myers, Robert P.; Blute, Michael L.; Gettman, Matthew T.

In: BJU International, Vol. 103, No. 4, 02.2009, p. 448-453.

Research output: Contribution to journalArticle

Krambeck, Amy ; DiMarco, David S. ; Rangel, Laureano J. ; Bergstralh, Eric J. ; Myers, Robert P. ; Blute, Michael L. ; Gettman, Matthew T. / Radical prostatectomy for prostatic adenocarcinoma : A matched comparison of open retropubic and robot-assisted techniques. In: BJU International. 2009 ; Vol. 103, No. 4. pp. 448-453.
@article{f4523dcd826545ba9ffc3cf3b50be7c8,
title = "Radical prostatectomy for prostatic adenocarcinoma: A matched comparison of open retropubic and robot-assisted techniques",
abstract = "OBJECTIVE: To assess the perioperative complications and early oncological results in a comparative study matching open radical retropubic (RRP) and robot-assisted radical prostatectomy (RARP) groups. PATIENTS AND METHODS: From August 2002 to December 2005 we identified 294 patients undergoing RARP for clinically localized prostate cancer. A comparison RRP group of 588 patients from the same period was matched 2:1 for surgical year, age, preoperative prostate-specific antigen level, clinical stage and biopsy Gleason grade. Perioperative complications were compared. Patients completed a standardized quality-of-life questionnaire. Pathological features were assessed and Kaplan-Meier estimates of biochemical progression-free survival (PFS) were compared. RESULTS: There was no significant difference in overall perioperative complications between the RARP and RRP groups (8.0{\%} vs 4.8{\%}, P = 0.064). Wound herniation was more common after RARP (1.0{\%} vs none, P = 0.038), and development of bladder neck contracture was more common after RRP (1.2{\%} vs 4.6{\%}; P < 0.018). The hospital stay was less after RARP (29.3{\%} vs 19.4{\%}, P = 0.004, for a stay of 1 day). At the 1-year follow-up there was no significant difference in continence (RARP 91.8{\%}, RRP 93.7{\%}, P = 0.344) or potency (RARP 70.0{\%}, RRP 62.8{\%}, P = 0.081) rates. The biochemical PFS was no different between treatments at 3 years (RARP 92.4{\%}, RRP 92.2{\%}; P = 0.69). CONCLUSION: There was no significant difference in overall early complication, long-term continence or potency rates between the RARP and RRP techniques. Furthermore, early oncological outcomes were similar, with equivalent margin positivity and PFS between the groups.",
keywords = "Laparoscopy, Prostate, Prostatic neoplasms, Robotics, Surgery",
author = "Amy Krambeck and DiMarco, {David S.} and Rangel, {Laureano J.} and Bergstralh, {Eric J.} and Myers, {Robert P.} and Blute, {Michael L.} and Gettman, {Matthew T.}",
year = "2009",
month = "2",
doi = "10.1111/j.1464-410X.2008.08012.x",
language = "English (US)",
volume = "103",
pages = "448--453",
journal = "BJU International",
issn = "1464-4096",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Radical prostatectomy for prostatic adenocarcinoma

T2 - A matched comparison of open retropubic and robot-assisted techniques

AU - Krambeck, Amy

AU - DiMarco, David S.

AU - Rangel, Laureano J.

AU - Bergstralh, Eric J.

AU - Myers, Robert P.

AU - Blute, Michael L.

AU - Gettman, Matthew T.

PY - 2009/2

Y1 - 2009/2

N2 - OBJECTIVE: To assess the perioperative complications and early oncological results in a comparative study matching open radical retropubic (RRP) and robot-assisted radical prostatectomy (RARP) groups. PATIENTS AND METHODS: From August 2002 to December 2005 we identified 294 patients undergoing RARP for clinically localized prostate cancer. A comparison RRP group of 588 patients from the same period was matched 2:1 for surgical year, age, preoperative prostate-specific antigen level, clinical stage and biopsy Gleason grade. Perioperative complications were compared. Patients completed a standardized quality-of-life questionnaire. Pathological features were assessed and Kaplan-Meier estimates of biochemical progression-free survival (PFS) were compared. RESULTS: There was no significant difference in overall perioperative complications between the RARP and RRP groups (8.0% vs 4.8%, P = 0.064). Wound herniation was more common after RARP (1.0% vs none, P = 0.038), and development of bladder neck contracture was more common after RRP (1.2% vs 4.6%; P < 0.018). The hospital stay was less after RARP (29.3% vs 19.4%, P = 0.004, for a stay of 1 day). At the 1-year follow-up there was no significant difference in continence (RARP 91.8%, RRP 93.7%, P = 0.344) or potency (RARP 70.0%, RRP 62.8%, P = 0.081) rates. The biochemical PFS was no different between treatments at 3 years (RARP 92.4%, RRP 92.2%; P = 0.69). CONCLUSION: There was no significant difference in overall early complication, long-term continence or potency rates between the RARP and RRP techniques. Furthermore, early oncological outcomes were similar, with equivalent margin positivity and PFS between the groups.

AB - OBJECTIVE: To assess the perioperative complications and early oncological results in a comparative study matching open radical retropubic (RRP) and robot-assisted radical prostatectomy (RARP) groups. PATIENTS AND METHODS: From August 2002 to December 2005 we identified 294 patients undergoing RARP for clinically localized prostate cancer. A comparison RRP group of 588 patients from the same period was matched 2:1 for surgical year, age, preoperative prostate-specific antigen level, clinical stage and biopsy Gleason grade. Perioperative complications were compared. Patients completed a standardized quality-of-life questionnaire. Pathological features were assessed and Kaplan-Meier estimates of biochemical progression-free survival (PFS) were compared. RESULTS: There was no significant difference in overall perioperative complications between the RARP and RRP groups (8.0% vs 4.8%, P = 0.064). Wound herniation was more common after RARP (1.0% vs none, P = 0.038), and development of bladder neck contracture was more common after RRP (1.2% vs 4.6%; P < 0.018). The hospital stay was less after RARP (29.3% vs 19.4%, P = 0.004, for a stay of 1 day). At the 1-year follow-up there was no significant difference in continence (RARP 91.8%, RRP 93.7%, P = 0.344) or potency (RARP 70.0%, RRP 62.8%, P = 0.081) rates. The biochemical PFS was no different between treatments at 3 years (RARP 92.4%, RRP 92.2%; P = 0.69). CONCLUSION: There was no significant difference in overall early complication, long-term continence or potency rates between the RARP and RRP techniques. Furthermore, early oncological outcomes were similar, with equivalent margin positivity and PFS between the groups.

KW - Laparoscopy

KW - Prostate

KW - Prostatic neoplasms

KW - Robotics

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=59249090997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59249090997&partnerID=8YFLogxK

U2 - 10.1111/j.1464-410X.2008.08012.x

DO - 10.1111/j.1464-410X.2008.08012.x

M3 - Article

C2 - 18778350

AN - SCOPUS:59249090997

VL - 103

SP - 448

EP - 453

JO - BJU International

JF - BJU International

SN - 1464-4096

IS - 4

ER -