Radiofrequency catheter ablation and nerve growth factor concentration in humans

Simon Kangavari, Yong Seog Oh, Shengmei Zhou, Ho Joong Youn, Man Young Lee, Wook Sung Jung, Tae ho Rho, Soon Jo Hong, Saibal Kar, Walter F. Kerwin, Charles D. Swerdlow, Eli S. Gang, Donna M. Gallik, Jeffrey S. Goodman, Yii Der Ida Chen, Peng Sheng Chen

Research output: Contribution to journalArticle

23 Scopus citations


Background: In animal models, expression of nerve growth factor (NGF) is increased after necrotic myocardial injury. Whether radiofrequency (RF) catheter ablation increases NGF expression in humans is unclear. Objectives: The purpose of this study was to determine NGF concentrations in the aorta, coronary sinus, and peripheral veins before and after RF ablation in patients. Methods: We sampled blood from aorta and either great cardiac vein (group 1, N = 18) or proximal (group 2, N = 20) coronary sinus before and after RF ablation. In group 3 (N = 21), peripheral venous blood was sampled before and after RF ablation and then up to postoperative day 7. In group 4 (N = 10), we sampled peripheral venous blood during diagnostic electrophysiologic study. The NGF concentration was determined by enzyme-linked immunosorbent assay. Transcardiac NGF concentration was the difference in NGF concentrations between coronary sinus and aorta. Results: There was no change in transcardiac NGF concentrations in groups 1 and 2. In group 3, the NGF level did not change significantly from before the procedure (17.10 ± 15.80 ng/mL) to immediately after the procedure (14.46 ± 10.36 ng/mL). However, NGF levels increased significantly to 31.24 ± 19.82 ng/mL (N = 21, P <.0001) on postoperative day 1, 26.23 ± 16.89 ng/mL (N = 20, P <.001) on postoperative day 2, and 22.01 ± 11.35 ng/mL (N = 16, P = .003) on postoperative day 3. NGF concentrations did not change significantly in group 4. Conclusion: RF ablation did not result in a detectable increase of transcardiac NGF concentration immediately after the procedure. However, the systemic NGF concentration increased significantly on postoperative days 1 to 3, suggesting that RF ablation resulted in increased NGF expression.

Original languageEnglish (US)
Pages (from-to)1150-1155
Number of pages6
JournalHeart Rhythm
Issue number10
StatePublished - Oct 1 2006
Externally publishedYes


  • Atrial fibrillation
  • Enzyme-linked immunosorbent assay
  • Nerve growth factor
  • Neurotrophic factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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  • Cite this

    Kangavari, S., Oh, Y. S., Zhou, S., Youn, H. J., Lee, M. Y., Jung, W. S., Rho, T. H., Hong, S. J., Kar, S., Kerwin, W. F., Swerdlow, C. D., Gang, E. S., Gallik, D. M., Goodman, J. S., Chen, Y. D. I., & Chen, P. S. (2006). Radiofrequency catheter ablation and nerve growth factor concentration in humans. Heart Rhythm, 3(10), 1150-1155.