Radiofrequency catheter ablation and nerve growth factor concentration in humans

Simon Kangavari, Yong Seog Oh, Shengmei Zhou, Ho Joong Youn, Man Young Lee, Wook Sung Jung, Tae ho Rho, Soon Jo Hong, Saibal Kar, Walter F. Kerwin, Charles D. Swerdlow, Eli S. Gang, Donna M. Gallik, Jeffrey S. Goodman, Yii Der Ida Chen, Peng-Sheng Chen

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: In animal models, expression of nerve growth factor (NGF) is increased after necrotic myocardial injury. Whether radiofrequency (RF) catheter ablation increases NGF expression in humans is unclear. Objectives: The purpose of this study was to determine NGF concentrations in the aorta, coronary sinus, and peripheral veins before and after RF ablation in patients. Methods: We sampled blood from aorta and either great cardiac vein (group 1, N = 18) or proximal (group 2, N = 20) coronary sinus before and after RF ablation. In group 3 (N = 21), peripheral venous blood was sampled before and after RF ablation and then up to postoperative day 7. In group 4 (N = 10), we sampled peripheral venous blood during diagnostic electrophysiologic study. The NGF concentration was determined by enzyme-linked immunosorbent assay. Transcardiac NGF concentration was the difference in NGF concentrations between coronary sinus and aorta. Results: There was no change in transcardiac NGF concentrations in groups 1 and 2. In group 3, the NGF level did not change significantly from before the procedure (17.10 ± 15.80 ng/mL) to immediately after the procedure (14.46 ± 10.36 ng/mL). However, NGF levels increased significantly to 31.24 ± 19.82 ng/mL (N = 21, P

Original languageEnglish (US)
Pages (from-to)1150-1155
Number of pages6
JournalHeart Rhythm
Volume3
Issue number10
DOIs
StatePublished - Oct 2006
Externally publishedYes

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Catheter Ablation
Nerve Growth Factor
Coronary Sinus
Aorta
Veins
Animal Models
Enzyme-Linked Immunosorbent Assay
Wounds and Injuries

Keywords

  • Atrial fibrillation
  • Enzyme-linked immunosorbent assay
  • Nerve growth factor
  • Neurotrophic factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kangavari, S., Oh, Y. S., Zhou, S., Youn, H. J., Lee, M. Y., Jung, W. S., ... Chen, P-S. (2006). Radiofrequency catheter ablation and nerve growth factor concentration in humans. Heart Rhythm, 3(10), 1150-1155. https://doi.org/10.1016/j.hrthm.2006.06.033

Radiofrequency catheter ablation and nerve growth factor concentration in humans. / Kangavari, Simon; Oh, Yong Seog; Zhou, Shengmei; Youn, Ho Joong; Lee, Man Young; Jung, Wook Sung; Rho, Tae ho; Hong, Soon Jo; Kar, Saibal; Kerwin, Walter F.; Swerdlow, Charles D.; Gang, Eli S.; Gallik, Donna M.; Goodman, Jeffrey S.; Chen, Yii Der Ida; Chen, Peng-Sheng.

In: Heart Rhythm, Vol. 3, No. 10, 10.2006, p. 1150-1155.

Research output: Contribution to journalArticle

Kangavari, S, Oh, YS, Zhou, S, Youn, HJ, Lee, MY, Jung, WS, Rho, TH, Hong, SJ, Kar, S, Kerwin, WF, Swerdlow, CD, Gang, ES, Gallik, DM, Goodman, JS, Chen, YDI & Chen, P-S 2006, 'Radiofrequency catheter ablation and nerve growth factor concentration in humans', Heart Rhythm, vol. 3, no. 10, pp. 1150-1155. https://doi.org/10.1016/j.hrthm.2006.06.033
Kangavari S, Oh YS, Zhou S, Youn HJ, Lee MY, Jung WS et al. Radiofrequency catheter ablation and nerve growth factor concentration in humans. Heart Rhythm. 2006 Oct;3(10):1150-1155. https://doi.org/10.1016/j.hrthm.2006.06.033
Kangavari, Simon ; Oh, Yong Seog ; Zhou, Shengmei ; Youn, Ho Joong ; Lee, Man Young ; Jung, Wook Sung ; Rho, Tae ho ; Hong, Soon Jo ; Kar, Saibal ; Kerwin, Walter F. ; Swerdlow, Charles D. ; Gang, Eli S. ; Gallik, Donna M. ; Goodman, Jeffrey S. ; Chen, Yii Der Ida ; Chen, Peng-Sheng. / Radiofrequency catheter ablation and nerve growth factor concentration in humans. In: Heart Rhythm. 2006 ; Vol. 3, No. 10. pp. 1150-1155.
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AU - Oh, Yong Seog

AU - Zhou, Shengmei

AU - Youn, Ho Joong

AU - Lee, Man Young

AU - Jung, Wook Sung

AU - Rho, Tae ho

AU - Hong, Soon Jo

AU - Kar, Saibal

AU - Kerwin, Walter F.

AU - Swerdlow, Charles D.

AU - Gang, Eli S.

AU - Gallik, Donna M.

AU - Goodman, Jeffrey S.

AU - Chen, Yii Der Ida

AU - Chen, Peng-Sheng

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KW - Atrial fibrillation

KW - Enzyme-linked immunosorbent assay

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