Radioligands targeting purinergic P2X7 receptor

Research output: Contribution to journalReview articlepeer-review


The purinergic P2X7 receptor (P2X7R) is an adenosine triphosphate (ATP) ligand-gated cationic channel receptor. P2X7R is closely associated with various inflammatory, immune, cancer, neurological, musculoskeletal and cardiovascular disorders. P2X7R is an interesting therapeutic target as well as molecular imaging target. This brief digest highlights the radioligands targeting P2X7R recently developed in drug discovery and molecular imaging agent development.

Original languageEnglish (US)
Article number127169
JournalBioorganic and Medicinal Chemistry Letters
Issue number12
StatePublished - Jun 15 2020


  • Drug discovery
  • Molecular imaging
  • Positron emission tomography (PET)
  • Purinergic P2X7 receptor (P2X7R)
  • Radioligands
  • Single photon emission computed tomography (SPECT)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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