Radioresistance secondary to low ph in human glial cells and Chinese hamster ovary cells

Erwin M. Röttinger, Marc Mendonca

Research output: Contribution to journalArticle

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Abstract

The influence of the extracellular pH on the radiosensitivity of human glial cells and Chinese hamster ovary cells was examined. The period of low pH varied from 0 to 96 hours in glial cells and from 0 to 48 hours in Chinese hamster cells. Maintenance of low pH after a dose of 10 Gy for at least 24 hours for glial cells and at least 6 hours for Chinese hamster cells improved survival by more than one order of magnitude at pH 6.4. Cellular inactivation by irradiation may be impaired by an extracellular pH at or below pH 6.7.

Original languageEnglish (US)
Pages (from-to)1309-1314
Number of pages6
JournalInternational journal of radiation oncology, biology, physics
Volume8
Issue number8
DOIs
StatePublished - Aug 1982

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Keywords

  • Chinese hamster cells
  • Extracellular milieu
  • Glioblastoma cells
  • Hydrogen ion concentration
  • Radioresistance
  • Radiosensitivity
  • pH

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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