Radioresistance secondary to low ph in human glial cells and Chinese hamster ovary cells

Erwin M. Röttinger, Marc Mendonca

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The influence of the extracellular pH on the radiosensitivity of human glial cells and Chinese hamster ovary cells was examined. The period of low pH varied from 0 to 96 hours in glial cells and from 0 to 48 hours in Chinese hamster cells. Maintenance of low pH after a dose of 10 Gy for at least 24 hours for glial cells and at least 6 hours for Chinese hamster cells improved survival by more than one order of magnitude at pH 6.4. Cellular inactivation by irradiation may be impaired by an extracellular pH at or below pH 6.7.

Original languageEnglish (US)
Pages (from-to)1309-1314
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume8
Issue number8
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

ovaries
hamsters
Cricetulus
Neuroglia
Ovary
Radiation Tolerance
radiation tolerance
deactivation
maintenance
Cell Survival
Maintenance
dosage
irradiation

Keywords

  • Chinese hamster cells
  • Extracellular milieu
  • Glioblastoma cells
  • Hydrogen ion concentration
  • pH
  • Radioresistance
  • Radiosensitivity

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Radioresistance secondary to low ph in human glial cells and Chinese hamster ovary cells. / Röttinger, Erwin M.; Mendonca, Marc.

In: International Journal of Radiation Oncology Biology Physics, Vol. 8, No. 8, 1982, p. 1309-1314.

Research output: Contribution to journalArticle

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