Radiosurgery for epilepsy: Clinical experience and potential antiepileptic mechanisms

Mark Quigg, John Rolston, Nicholas M. Barbaro

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


Stereotactic radiosurgery, well established in the noninvasive treatment of focal lesions that are otherwise difficult to access through open surgery, is an emerging technology in the treatment of focal epileptic lesions. Recent studies suggest that seizures from hypothalamic hamartomas and mesial temporal lobe epilepsy remit at clinically significant rates with radiosurgery, but large variations among different studies have raised questions about appropriate treatment protocols and mechanisms. Proposed anticonvulsant mechanisms include neuromodulatory effects or ischemic necrosis of epileptic tissue. An ongoing trial that directly compares efficacy, morbidities, and cost of radiosurgery versus open surgery for mesial temporal lobe epilepsy is underway.

Original languageEnglish (US)
Pages (from-to)7-15
Number of pages9
Issue number1
StatePublished - Jan 2012


  • Epilepsy surgery
  • Gamma Knife
  • Mesial temporal lobe epilepsy
  • Partial seizure
  • Radiosurgery

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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