Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers

Mingzhang Gao, Kathy Miller, George W. Sledge, Qi-Huang Zheng

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Four carbon-11-labeled camptothecin derivatives, 9-[11C]methoxy- 20(S)-camptothecin ([11C]5), 10-[11C]methoxy-20(S)- camptothecin ([11C]7), 9-nitro-10-[11C]methoxy-20(S)- camptothecin ([11C]9), and 9-[([11C]trimethylamino)methyl] -10-hydroxy-20(S)-camptothecin ([11C]11), have been synthesized as potential positron emission tomography tracers for imaging of topoisomerase I in cancers.

Original languageEnglish
Pages (from-to)3865-3869
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number17
DOIs
StatePublished - Sep 1 2005

Fingerprint

irinotecan
Camptothecin
Type I DNA Topoisomerase
Positron emission tomography
Positron-Emission Tomography
Carbon
Derivatives
Imaging techniques
Neoplasms
10-methoxycamptothecin

Keywords

  • Cancer
  • Carbon-11-labeled camptothecin derivatives
  • Positron emission tomography
  • Radiosynthesis
  • Topoisomerase I
  • Tracer

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

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title = "Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers",
abstract = "Four carbon-11-labeled camptothecin derivatives, 9-[11C]methoxy- 20(S)-camptothecin ([11C]5), 10-[11C]methoxy-20(S)- camptothecin ([11C]7), 9-nitro-10-[11C]methoxy-20(S)- camptothecin ([11C]9), and 9-[([11C]trimethylamino)methyl] -10-hydroxy-20(S)-camptothecin ([11C]11), have been synthesized as potential positron emission tomography tracers for imaging of topoisomerase I in cancers.",
keywords = "Cancer, Carbon-11-labeled camptothecin derivatives, Positron emission tomography, Radiosynthesis, Topoisomerase I, Tracer",
author = "Mingzhang Gao and Kathy Miller and Sledge, {George W.} and Qi-Huang Zheng",
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T1 - Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers

AU - Gao, Mingzhang

AU - Miller, Kathy

AU - Sledge, George W.

AU - Zheng, Qi-Huang

PY - 2005/9/1

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KW - Positron emission tomography

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KW - Topoisomerase I

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