Radiotherapy-induced osteoporosis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter highlights the understanding of the skeletal consequences of radiation exposure in cancer patients, and the potential cellular and molecular mechanisms responsible for radiation-induced bone loss. Patients receiving radiotherapy (RT) for pelvic tumors including cervical, rectal, and anal cancers have increased risk of hip fracture relative to cancer patients who undergo surgery or chemotherapy alone. Systemic reduction in bone mineral density (BMD) has been detected in cancer patients within the first year of radiotherapy. In animal models, acute deterioration of trabecular bone has been detected following ionizing radiation. Ionizing radiation may have a direct effect on osteoclast precursor cells. Changes in bone strength after irradiation may be influenced by both architectural and material properties. In vitro, osteocytes appear more radiosensitive than osteoblasts when compared head-to-head in proliferation and apoptosis assays. A reciprocal relationship has been identified clinically between bone marrow adiposity and bone volume in cancer patients treated with radiotherapy.

Original languageEnglish (US)
Title of host publicationPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
Publisherwiley
Pages788-792
Number of pages5
ISBN (Electronic)9781119266594
ISBN (Print)9781119266563
DOIs
StatePublished - Jan 1 2018

Fingerprint

Radiotherapy
Osteoporosis
Bone
Neoplasms
Ionizing Radiation
Bone and Bones
Ionizing radiation
Anus Neoplasms
Osteocytes
Adiposity
Hip Fractures
Radiation
Osteoclasts
Rectal Neoplasms
Osteoblasts
Chemotherapy
Uterine Cervical Neoplasms
Bone Density
Animal Models
Surgery

Keywords

  • Bone marrow adiposity
  • Bone mineral density
  • Osteoblasts
  • Osteoclast precursor cells
  • Osteocytes
  • Radiation-induced bone loss
  • Radiosensitive
  • Radiotherapy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Wright, L. (2018). Radiotherapy-induced osteoporosis. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (pp. 788-792). wiley. https://doi.org/10.1002/9781119266594.ch102

Radiotherapy-induced osteoporosis. / Wright, Laura.

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, 2018. p. 788-792.

Research output: Chapter in Book/Report/Conference proceedingChapter

Wright, L 2018, Radiotherapy-induced osteoporosis. in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, pp. 788-792. https://doi.org/10.1002/9781119266594.ch102
Wright L. Radiotherapy-induced osteoporosis. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley. 2018. p. 788-792 https://doi.org/10.1002/9781119266594.ch102
Wright, Laura. / Radiotherapy-induced osteoporosis. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, 2018. pp. 788-792
@inbook{0cf7c3adbd80438abe534cb1c170bb1a,
title = "Radiotherapy-induced osteoporosis",
abstract = "This chapter highlights the understanding of the skeletal consequences of radiation exposure in cancer patients, and the potential cellular and molecular mechanisms responsible for radiation-induced bone loss. Patients receiving radiotherapy (RT) for pelvic tumors including cervical, rectal, and anal cancers have increased risk of hip fracture relative to cancer patients who undergo surgery or chemotherapy alone. Systemic reduction in bone mineral density (BMD) has been detected in cancer patients within the first year of radiotherapy. In animal models, acute deterioration of trabecular bone has been detected following ionizing radiation. Ionizing radiation may have a direct effect on osteoclast precursor cells. Changes in bone strength after irradiation may be influenced by both architectural and material properties. In vitro, osteocytes appear more radiosensitive than osteoblasts when compared head-to-head in proliferation and apoptosis assays. A reciprocal relationship has been identified clinically between bone marrow adiposity and bone volume in cancer patients treated with radiotherapy.",
keywords = "Bone marrow adiposity, Bone mineral density, Osteoblasts, Osteoclast precursor cells, Osteocytes, Radiation-induced bone loss, Radiosensitive, Radiotherapy",
author = "Laura Wright",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/9781119266594.ch102",
language = "English (US)",
isbn = "9781119266563",
pages = "788--792",
booktitle = "Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism",
publisher = "wiley",

}

TY - CHAP

T1 - Radiotherapy-induced osteoporosis

AU - Wright, Laura

PY - 2018/1/1

Y1 - 2018/1/1

N2 - This chapter highlights the understanding of the skeletal consequences of radiation exposure in cancer patients, and the potential cellular and molecular mechanisms responsible for radiation-induced bone loss. Patients receiving radiotherapy (RT) for pelvic tumors including cervical, rectal, and anal cancers have increased risk of hip fracture relative to cancer patients who undergo surgery or chemotherapy alone. Systemic reduction in bone mineral density (BMD) has been detected in cancer patients within the first year of radiotherapy. In animal models, acute deterioration of trabecular bone has been detected following ionizing radiation. Ionizing radiation may have a direct effect on osteoclast precursor cells. Changes in bone strength after irradiation may be influenced by both architectural and material properties. In vitro, osteocytes appear more radiosensitive than osteoblasts when compared head-to-head in proliferation and apoptosis assays. A reciprocal relationship has been identified clinically between bone marrow adiposity and bone volume in cancer patients treated with radiotherapy.

AB - This chapter highlights the understanding of the skeletal consequences of radiation exposure in cancer patients, and the potential cellular and molecular mechanisms responsible for radiation-induced bone loss. Patients receiving radiotherapy (RT) for pelvic tumors including cervical, rectal, and anal cancers have increased risk of hip fracture relative to cancer patients who undergo surgery or chemotherapy alone. Systemic reduction in bone mineral density (BMD) has been detected in cancer patients within the first year of radiotherapy. In animal models, acute deterioration of trabecular bone has been detected following ionizing radiation. Ionizing radiation may have a direct effect on osteoclast precursor cells. Changes in bone strength after irradiation may be influenced by both architectural and material properties. In vitro, osteocytes appear more radiosensitive than osteoblasts when compared head-to-head in proliferation and apoptosis assays. A reciprocal relationship has been identified clinically between bone marrow adiposity and bone volume in cancer patients treated with radiotherapy.

KW - Bone marrow adiposity

KW - Bone mineral density

KW - Osteoblasts

KW - Osteoclast precursor cells

KW - Osteocytes

KW - Radiation-induced bone loss

KW - Radiosensitive

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=85060596907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060596907&partnerID=8YFLogxK

U2 - 10.1002/9781119266594.ch102

DO - 10.1002/9781119266594.ch102

M3 - Chapter

AN - SCOPUS:85060596907

SN - 9781119266563

SP - 788

EP - 792

BT - Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

PB - wiley

ER -