Raloxifene reduces skeletal fractures in an animal model of osteogenesis imperfecta

Alycia G. Berman, Joseph M. Wallace, Zachary R. Bart, Matthew Allen

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Osteogenesis imperfecta (OI) is a genetic disease of Type I collagen and collagen-associated pathways that results in brittle bone behavior characterized by fracture and reduced mechanical properties. Based on previous work in our laboratory showing that raloxifene (RAL) can significantly improve bone mechanical properties through non-cellular mechanisms, we hypothesized that raloxifene would improve the mechanical properties of OI bone. In experiment 1, tibiae from female wild type (WT) and homozygous oim mice were subjected to in vitro soaking in RAL followed by mechanical tests. RAL soaking resulted in significantly higher post-yield displacement (+. 75% in WT, +. 472% in oim; p.

Original languageEnglish (US)
JournalMatrix Biology
DOIs
StateAccepted/In press - Sep 30 2015

Keywords

  • Bone mechanical properties
  • OI
  • Oim/oim
  • SERM

ASJC Scopus subject areas

  • Molecular Biology

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