Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle

Andrew P. Evan, James E. Lingeman, Fredric L. Coe, Joan H. Parks, Sharon B. Bledsoe, Youzhi Shao, Andre J. Sommer, Ryan F. Paterson, Ramsay L. Kuo, Marc Grynpas

Research output: Contribution to journalArticle

441 Scopus citations

Abstract

Our purpose here is to test the hypothesis that Randall's plaques, calcium phosphate deposits in kidneys of patients with calcium renal stones, arise in unique anatomical regions of the kidney, their formation conditioned by specific stone-forming pathophysiologies. To test this hypothesis, we performed intraoperative biopsies of plaques in kidneys of idiopathic-calcium-stone formers and patients with stones due to obesity-related bypass procedures and obtained papillary specimens from non-stone formers after nephrectomy. Plaque originates in the basement membranes of the thin loops of Henle and spreads from there through the interstitium to beneath the urothelium. Patients who have undergone bypass surgery do not produce such plaque but instead form intratubular hydroxyapatite crystals in collecting ducts. Non-stone formers also do not form plaque. Plaque is specific to certain kinds of stone-forming patients and is initiated specifically in thin-limb basement membranes by mechanisms that remain to be elucidated.

Original languageEnglish (US)
Pages (from-to)607-616
Number of pages10
JournalJournal of Clinical Investigation
Volume111
Issue number5
DOIs
StatePublished - Mar 2003

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle'. Together they form a unique fingerprint.

  • Cite this

    Evan, A. P., Lingeman, J. E., Coe, F. L., Parks, J. H., Bledsoe, S. B., Shao, Y., Sommer, A. J., Paterson, R. F., Kuo, R. L., & Grynpas, M. (2003). Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle. Journal of Clinical Investigation, 111(5), 607-616. https://doi.org/10.1172/JCI17038