Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle

Andrew P. Evan, James E. Lingeman, Fredric L. Coe, Joan H. Parks, Sharon B. Bledsoe, Youzhi Shao, Andre J. Sommer, Ryan F. Paterson, Ramsay L. Kuo, Marc Grynpas

Research output: Contribution to journalArticle

426 Citations (Scopus)

Abstract

Our purpose here is to test the hypothesis that Randall's plaques, calcium phosphate deposits in kidneys of patients with calcium renal stones, arise in unique anatomical regions of the kidney, their formation conditioned by specific stone-forming pathophysiologies. To test this hypothesis, we performed intraoperative biopsies of plaques in kidneys of idiopathic-calcium-stone formers and patients with stones due to obesity-related bypass procedures and obtained papillary specimens from non-stone formers after nephrectomy. Plaque originates in the basement membranes of the thin loops of Henle and spreads from there through the interstitium to beneath the urothelium. Patients who have undergone bypass surgery do not produce such plaque but instead form intratubular hydroxyapatite crystals in collecting ducts. Non-stone formers also do not form plaque. Plaque is specific to certain kinds of stone-forming patients and is initiated specifically in thin-limb basement membranes by mechanisms that remain to be elucidated.

Original languageEnglish (US)
Pages (from-to)607-616
Number of pages10
JournalJournal of Clinical Investigation
Volume111
Issue number5
DOIs
StatePublished - Mar 2003

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Loop of Henle
Nephrolithiasis
Basement Membrane
Kidney
Calcium
Urothelium
Durapatite
Nephrectomy
Extremities
Obesity
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

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Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle. / Evan, Andrew P.; Lingeman, James E.; Coe, Fredric L.; Parks, Joan H.; Bledsoe, Sharon B.; Shao, Youzhi; Sommer, Andre J.; Paterson, Ryan F.; Kuo, Ramsay L.; Grynpas, Marc.

In: Journal of Clinical Investigation, Vol. 111, No. 5, 03.2003, p. 607-616.

Research output: Contribution to journalArticle

Evan, AP, Lingeman, JE, Coe, FL, Parks, JH, Bledsoe, SB, Shao, Y, Sommer, AJ, Paterson, RF, Kuo, RL & Grynpas, M 2003, 'Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle', Journal of Clinical Investigation, vol. 111, no. 5, pp. 607-616. https://doi.org/10.1172/JCI17038
Evan, Andrew P. ; Lingeman, James E. ; Coe, Fredric L. ; Parks, Joan H. ; Bledsoe, Sharon B. ; Shao, Youzhi ; Sommer, Andre J. ; Paterson, Ryan F. ; Kuo, Ramsay L. ; Grynpas, Marc. / Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle. In: Journal of Clinical Investigation. 2003 ; Vol. 111, No. 5. pp. 607-616.
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