Randall's plaques

Michel Daudon, Olivier Traxer, James Williams, Dominique C. Bazin

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)

Abstract

First described by Alexander Randall in the 1930s, carbapatite plaques formed in the interstitium of the inner medulla are now a major cause for calcium oxalate stone formation in western countries. At least 50% of all calcium stone formers (and even more than 75% of patients in the United States) exhibit such calcified deposits beneath and at the surface of the papillary epithelium as observed by endoscopic examination of kidney papillae. On the other hand, a majority of spontaneously passed calcium oxalate monohydrate stones exhibit a peculiar morphology suggestive of stone nucleation from a Randall's plaque. The stones developed from a papillary plaque are easily identified by microscopic examination due to the presence of a concave, depressed zone ("umbilication") at their surface, which corresponds to the attachment site at the tip of the papilla. The origin of the calcified deposits is the basement membrane of the deep thin Henle's loops. Calcium phosphate then spreads out through the interstitium of the inner medulla. The mechanisms involved in the formation of these plaques are not yet entirely clarified. Metabolic examination of urine suggests a predominant role of hypercalciuria in concordance with a high urine pH and a high phosphate concentration in the interstitium and a possible link with diet. Low diuresis is another factor often found in patients who exhibit stones developed from a Randall's plaque. As observed by electron microscopy from both tissue and stones, it appears that Randall's plaques may extend around the vasa recta and collecting ducts, which may be pulled out of the tissue when the stone breaks away from the papilla.

Original languageEnglish
Title of host publicationUrinary Tract Stone Disease
PublisherSpringer London
Pages103-112
Number of pages10
ISBN (Print)9781848003613
DOIs
StatePublished - 2011

Fingerprint

Calcium Oxalate
Urine
Kidney Medulla
Loop of Henle
Hypercalciuria
Diuresis
Rectum
Basement Membrane
Electron Microscopy
Epithelium
Phosphates
Diet
Calcium
calcium phosphate
carboapatite

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Daudon, M., Traxer, O., Williams, J., & Bazin, D. C. (2011). Randall's plaques. In Urinary Tract Stone Disease (pp. 103-112). Springer London. https://doi.org/10.1007/978-1-84800-362-0_7

Randall's plaques. / Daudon, Michel; Traxer, Olivier; Williams, James; Bazin, Dominique C.

Urinary Tract Stone Disease. Springer London, 2011. p. 103-112.

Research output: Chapter in Book/Report/Conference proceedingChapter

Daudon, M, Traxer, O, Williams, J & Bazin, DC 2011, Randall's plaques. in Urinary Tract Stone Disease. Springer London, pp. 103-112. https://doi.org/10.1007/978-1-84800-362-0_7
Daudon M, Traxer O, Williams J, Bazin DC. Randall's plaques. In Urinary Tract Stone Disease. Springer London. 2011. p. 103-112 https://doi.org/10.1007/978-1-84800-362-0_7
Daudon, Michel ; Traxer, Olivier ; Williams, James ; Bazin, Dominique C. / Randall's plaques. Urinary Tract Stone Disease. Springer London, 2011. pp. 103-112
@inbook{44c3f5e2da644ffa9d742022168cbd54,
title = "Randall's plaques",
abstract = "First described by Alexander Randall in the 1930s, carbapatite plaques formed in the interstitium of the inner medulla are now a major cause for calcium oxalate stone formation in western countries. At least 50{\%} of all calcium stone formers (and even more than 75{\%} of patients in the United States) exhibit such calcified deposits beneath and at the surface of the papillary epithelium as observed by endoscopic examination of kidney papillae. On the other hand, a majority of spontaneously passed calcium oxalate monohydrate stones exhibit a peculiar morphology suggestive of stone nucleation from a Randall's plaque. The stones developed from a papillary plaque are easily identified by microscopic examination due to the presence of a concave, depressed zone ({"}umbilication{"}) at their surface, which corresponds to the attachment site at the tip of the papilla. The origin of the calcified deposits is the basement membrane of the deep thin Henle's loops. Calcium phosphate then spreads out through the interstitium of the inner medulla. The mechanisms involved in the formation of these plaques are not yet entirely clarified. Metabolic examination of urine suggests a predominant role of hypercalciuria in concordance with a high urine pH and a high phosphate concentration in the interstitium and a possible link with diet. Low diuresis is another factor often found in patients who exhibit stones developed from a Randall's plaque. As observed by electron microscopy from both tissue and stones, it appears that Randall's plaques may extend around the vasa recta and collecting ducts, which may be pulled out of the tissue when the stone breaks away from the papilla.",
author = "Michel Daudon and Olivier Traxer and James Williams and Bazin, {Dominique C.}",
year = "2011",
doi = "10.1007/978-1-84800-362-0_7",
language = "English",
isbn = "9781848003613",
pages = "103--112",
booktitle = "Urinary Tract Stone Disease",
publisher = "Springer London",

}

TY - CHAP

T1 - Randall's plaques

AU - Daudon, Michel

AU - Traxer, Olivier

AU - Williams, James

AU - Bazin, Dominique C.

PY - 2011

Y1 - 2011

N2 - First described by Alexander Randall in the 1930s, carbapatite plaques formed in the interstitium of the inner medulla are now a major cause for calcium oxalate stone formation in western countries. At least 50% of all calcium stone formers (and even more than 75% of patients in the United States) exhibit such calcified deposits beneath and at the surface of the papillary epithelium as observed by endoscopic examination of kidney papillae. On the other hand, a majority of spontaneously passed calcium oxalate monohydrate stones exhibit a peculiar morphology suggestive of stone nucleation from a Randall's plaque. The stones developed from a papillary plaque are easily identified by microscopic examination due to the presence of a concave, depressed zone ("umbilication") at their surface, which corresponds to the attachment site at the tip of the papilla. The origin of the calcified deposits is the basement membrane of the deep thin Henle's loops. Calcium phosphate then spreads out through the interstitium of the inner medulla. The mechanisms involved in the formation of these plaques are not yet entirely clarified. Metabolic examination of urine suggests a predominant role of hypercalciuria in concordance with a high urine pH and a high phosphate concentration in the interstitium and a possible link with diet. Low diuresis is another factor often found in patients who exhibit stones developed from a Randall's plaque. As observed by electron microscopy from both tissue and stones, it appears that Randall's plaques may extend around the vasa recta and collecting ducts, which may be pulled out of the tissue when the stone breaks away from the papilla.

AB - First described by Alexander Randall in the 1930s, carbapatite plaques formed in the interstitium of the inner medulla are now a major cause for calcium oxalate stone formation in western countries. At least 50% of all calcium stone formers (and even more than 75% of patients in the United States) exhibit such calcified deposits beneath and at the surface of the papillary epithelium as observed by endoscopic examination of kidney papillae. On the other hand, a majority of spontaneously passed calcium oxalate monohydrate stones exhibit a peculiar morphology suggestive of stone nucleation from a Randall's plaque. The stones developed from a papillary plaque are easily identified by microscopic examination due to the presence of a concave, depressed zone ("umbilication") at their surface, which corresponds to the attachment site at the tip of the papilla. The origin of the calcified deposits is the basement membrane of the deep thin Henle's loops. Calcium phosphate then spreads out through the interstitium of the inner medulla. The mechanisms involved in the formation of these plaques are not yet entirely clarified. Metabolic examination of urine suggests a predominant role of hypercalciuria in concordance with a high urine pH and a high phosphate concentration in the interstitium and a possible link with diet. Low diuresis is another factor often found in patients who exhibit stones developed from a Randall's plaque. As observed by electron microscopy from both tissue and stones, it appears that Randall's plaques may extend around the vasa recta and collecting ducts, which may be pulled out of the tissue when the stone breaks away from the papilla.

UR - http://www.scopus.com/inward/record.url?scp=84875586848&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875586848&partnerID=8YFLogxK

U2 - 10.1007/978-1-84800-362-0_7

DO - 10.1007/978-1-84800-362-0_7

M3 - Chapter

SN - 9781848003613

SP - 103

EP - 112

BT - Urinary Tract Stone Disease

PB - Springer London

ER -