Randomised study of the effects of fluoride and time on in situ remineralisation of acid-softened enamel

M. Nehme, C. R. Parkinson, D. T. Zero, A. T. Hara

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objectives: This single-centre, randomised, crossover study used a short-term in situ dental erosion remineralisation model to explore the remineralisation of acid-softened enamel in the 4-h period immediately following brushing with an anti-erosion, dentin hypersensitivity test dentifrice containing 1150 ppm fluoride (as sodium fluoride [NaF]) or a placebo dentifrice with no fluoride. Materials and methods: Fifty participants wearing a palatal appliance holding surface-softened bovine enamel specimens brushed their natural teeth with their assigned dentifrice. Specimens were removed at 5-, 10-, 15-, 30-, 60-, 120- and 240-min post brushing. Enamel remineralisation effect was evaluated at each timepoint by percent surface microhardness recovery (%SMHR) and enamel fluoride uptake (EFU). After a second in vitro erosive challenge, the percent relative erosion resistance (%RER) was calculated. Results: Statistically significant differences in %SMHR were observed for the test dentifrice compared with the placebo dentifrice from the 60-min timepoint onwards (all p < 0.02; mean difference of 8.66 [95% CI 3.46, 13.87] at 60 min). At each specimen removal time, %RER and EFU were statistically significantly higher for the test dentifrice compared with the placebo dentifrice (p < 0.0001 for all). No treatment-related or serious adverse events were reported. Conclusions: The NaF-containing anti-erosion, dentin hypersensitivity dentifrice improved remineralisation of acid-softened enamel starting at 60 min of intra-oral exposure. It also improved enamel erosion resistance and fluoride uptake as early as 5 min after exposure to fluoridated dentifrice slurry. Clinical relevance: Brushing with a NaF-containing dentifrice can rapidly improve remineralisation, enamel erosion resistance and fluoride uptake.

Original languageEnglish (US)
Pages (from-to)4455-4463
Number of pages9
JournalClinical oral investigations
Volume23
Issue number12
DOIs
StatePublished - Dec 1 2019

Keywords

  • Dental erosion
  • Dentifrice
  • Fluoride
  • In situ model
  • Surface microhardness

ASJC Scopus subject areas

  • Dentistry(all)

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