Randomized controlled pilot study of mindfulness-based stress reduction for persistently fatigued cancer survivors

Shelley A. Johns, Linda F. Brown, Kathleen Beck-Coon, Patrick O. Monahan, Yan Tong, Kurt Kroenke

Research output: Contribution to journalArticle

63 Scopus citations


Objective Cancer-related fatigue (CRF) is one of the most common, persistent, and disabling symptoms associated with cancer and its treatment. Evidence-based treatments that are acceptable to patients are critically needed. This study examined the efficacy of mindfulness-based stress reduction (MBSR) for CRF and related symptoms. Method A sample of 35 cancer survivors with clinically significant CRF was randomly assigned to a 7-week MBSR-based intervention or wait-list control group. The intervention group received training in mindfulness meditation, yoga, and self-regulatory responses to stress. Fatigue interference (primary outcome) and a variety of secondary outcomes (e.g., fatigue severity, vitality, disability, depression, anxiety, and sleep disturbance) were assessed at baseline, post-intervention, and 1-month follow-up. Bonferroni correction was employed to account for multiple comparisons. Controls received the intervention after the 1-month follow-up. Participants in both groups were followed for 6months after completing their respective MBSR courses to assess maintenance of effects. Results Compared to controls, the MBSR group reported large post-intervention reductions as assessed by effect sizes (d) in the primary outcome, fatigue interference (d=-1.43, p<0.001), along with fatigue severity (d=-1.55, p<0.001), vitality (d=1.29, p<0.001), depression (d=-1.30, p<0.001), and sleep disturbance (d=-0.74, p=0.001). Results were maintained or strengthened at 1-month follow-up, the point at which significant improvements in disability (d=-1.22, p<0.002) and anxiety (d=-0.98, p=0.002) occurred. Improvements in all outcomes were maintained 6months after completing the course. MBSR adherence was high, with 90% attendance across groups and high rates of participant-reported home practice of mindfulness. Conclusions Mindfulness-based stress reduction is a promising treatment for CRF and associated symptoms.

Original languageEnglish (US)
Pages (from-to)885-893
Number of pages9
Issue number8
StatePublished - Aug 1 2015


  • cancer
  • cancer-related fatigue
  • MBSR
  • meditation
  • mindfulness
  • oncology

ASJC Scopus subject areas

  • Oncology
  • Psychiatry and Mental health
  • Experimental and Cognitive Psychology

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