Randomized trial of medical treatment versus hysterectomy for abnormal uterine bleeding

Resource use in the Medicine or Surgery (Ms) trial

Jonathan Showstack, Feng Lin, Lee A. Learman, Eric Vittinghoff, Miriam Kuppermann, R. Edward Varner, Robert L. Summitt, S. Gene McNeeley, Holly Richter, Stephen Hulley, A. Eugene Washington

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: This study was undertaken to compare resource use outcomes for participants in the Medicine or Surgery (Ms) randomized trial. Study design: In a randomized controlled trial, we compared resources used during a 24-month follow-up period by women with abnormal uterine bleeding who were randomly assigned to either expanded medical treatment or hysterectomy. Results: Women randomly assigned to hysterectomy used significantly more resources (medicine = $4479, hysterectomy = $6777; P = .03), with almost all the difference caused by the hysterectomy procedure. Fifty-three percent of women randomly assigned to medicine had a hysterectomy during the follow-up period; women who were able to continue on medical therapy had mean total resource use of $2595 compared with $6128 for medicine patients who eventually had surgery. Conclusion: For women with abnormal uterine bleeding refractory to cyclic medroxyprogesterone acetate, compared with expanded medical treatment, hysterectomy increases resource use significantly and results in better clinical and 6-month quality-of-life outcomes.

Original languageEnglish (US)
Pages (from-to)332-338
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume194
Issue number2
DOIs
StatePublished - Feb 2006
Externally publishedYes

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Uterine Hemorrhage
Hysterectomy
Medicine
Therapeutics
Medroxyprogesterone Acetate
Randomized Controlled Trials
Quality of Life

Keywords

  • Abnormal uterine bleeding
  • Costs
  • Hysterectomy

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Randomized trial of medical treatment versus hysterectomy for abnormal uterine bleeding : Resource use in the Medicine or Surgery (Ms) trial. / Showstack, Jonathan; Lin, Feng; Learman, Lee A.; Vittinghoff, Eric; Kuppermann, Miriam; Varner, R. Edward; Summitt, Robert L.; McNeeley, S. Gene; Richter, Holly; Hulley, Stephen; Washington, A. Eugene.

In: American Journal of Obstetrics and Gynecology, Vol. 194, No. 2, 02.2006, p. 332-338.

Research output: Contribution to journalArticle

Showstack, J, Lin, F, Learman, LA, Vittinghoff, E, Kuppermann, M, Varner, RE, Summitt, RL, McNeeley, SG, Richter, H, Hulley, S & Washington, AE 2006, 'Randomized trial of medical treatment versus hysterectomy for abnormal uterine bleeding: Resource use in the Medicine or Surgery (Ms) trial', American Journal of Obstetrics and Gynecology, vol. 194, no. 2, pp. 332-338. https://doi.org/10.1016/j.ajog.2005.08.014
Showstack, Jonathan ; Lin, Feng ; Learman, Lee A. ; Vittinghoff, Eric ; Kuppermann, Miriam ; Varner, R. Edward ; Summitt, Robert L. ; McNeeley, S. Gene ; Richter, Holly ; Hulley, Stephen ; Washington, A. Eugene. / Randomized trial of medical treatment versus hysterectomy for abnormal uterine bleeding : Resource use in the Medicine or Surgery (Ms) trial. In: American Journal of Obstetrics and Gynecology. 2006 ; Vol. 194, No. 2. pp. 332-338.
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