Rapid Decrease in Liver Graft Steatosis in the Early Post-transplant Period: A Blinded and Randomized Study

Research output: Contribution to journalArticle

Abstract

Aims: Previous research suggests a rapid post-transplant decrease in liver steatosis. With increased use of liver grafts with steatosis, better understanding of this post-transplant change will facilitate successful liver transplantation. This study compares liver reperfusion biopsies with early post-transplant surveillance biopsies to evaluate and quantitate change in steatosis. Methods: All liver grafts with ≥ 10% steatosis were extracted for analysis. Allograft biopsies on day 0 and day 3 post-transplant were randomly read, in a blinded fashion, by a single, experienced liver pathologist. Ten non-steatotic grafts were interspersed as controls. Slides were scored for macro-, micro-, and total steatosis. Results: Overall, 151 subjects with steatosis were available for study. A decrease in steatosis was seen for most grafts: microvesicular (69%), macrovesicular (64%), and total steatosis (77%). There was a greater decrease in steatosis for grafts with high baseline steatosis (> 40% baseline steatosis with -30% reduction; 20%-39% baseline steatosis with -15% reduction; and < 20% baseline steatosis with -5% reduction). Conclusions: These results confirm a marked post-transplant decrease in steatosis that occurs within 3 to 5 days for most liver grafts with steatosis. These findings support the continued use of liver grafts with steatosis as this pathology appears to resolve quickly after transplant.

Original languageEnglish (US)
Pages (from-to)284-288
Number of pages5
JournalTransplantation proceedings
Volume52
Issue number1
DOIs
StatePublished - Jan 1 2020

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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