Rapid identification of improved protein ligands using peptoid microarrays

Hyun-Suk Lim, M. Muralidhar Reddy, Xiangshu Xiao, Johnnie Wilson, Rosemary Wilson, Steven Connell, Thomas Kodadek

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A rapid array-based protocol is presented by which a modest affinity protein-binding small molecule can be appended to a library of peptoids via click chemistry. The array can then be screened for improved ligands that exhibit a higher affinity for the protein target.

Original languageEnglish (US)
Pages (from-to)3866-3869
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number14
DOIs
StatePublished - Jul 15 2009
Externally publishedYes

Fingerprint

Peptoids
Click Chemistry
Microarrays
Protein Binding
Ligands
Molecules
Proteins

Keywords

  • Click chemistry
  • Combinatorial chemistry
  • Library screening
  • Microarray
  • Peptoid

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Lim, H-S., Muralidhar Reddy, M., Xiao, X., Wilson, J., Wilson, R., Connell, S., & Kodadek, T. (2009). Rapid identification of improved protein ligands using peptoid microarrays. Bioorganic and Medicinal Chemistry Letters, 19(14), 3866-3869. https://doi.org/10.1016/j.bmcl.2009.03.153

Rapid identification of improved protein ligands using peptoid microarrays. / Lim, Hyun-Suk; Muralidhar Reddy, M.; Xiao, Xiangshu; Wilson, Johnnie; Wilson, Rosemary; Connell, Steven; Kodadek, Thomas.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 14, 15.07.2009, p. 3866-3869.

Research output: Contribution to journalArticle

Lim, H-S, Muralidhar Reddy, M, Xiao, X, Wilson, J, Wilson, R, Connell, S & Kodadek, T 2009, 'Rapid identification of improved protein ligands using peptoid microarrays', Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 14, pp. 3866-3869. https://doi.org/10.1016/j.bmcl.2009.03.153
Lim, Hyun-Suk ; Muralidhar Reddy, M. ; Xiao, Xiangshu ; Wilson, Johnnie ; Wilson, Rosemary ; Connell, Steven ; Kodadek, Thomas. / Rapid identification of improved protein ligands using peptoid microarrays. In: Bioorganic and Medicinal Chemistry Letters. 2009 ; Vol. 19, No. 14. pp. 3866-3869.
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