Rapid identification of the pharmacophore in a peptoid inhibitor of the proteasome regulatory particle

Hyun Suk Lim, Chase T. Archer, Young Chan Kim, Troy Hutchens, Thomas Kodadek

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Here we report a simple and effective method to identify the minimal pharmacophore in the first peptoid inhibitor of the 19S proteasome regulatory particle, which has led to the development of a derivative that exhibits improved cellular activity, presumably due to a reduction in mass of about two-fold and the elimination of positively charged lysine-like residues.

Original languageEnglish (US)
Pages (from-to)1064-1066
Number of pages3
JournalChemical Communications
Issue number9
DOIs
StatePublished - Mar 4 2008
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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