Rapid modulation of a 64 K Dalton fibroblast protein

a PDGF mediated early cellular event

Jai Pal Singh, Paul D. Bonin, Lonnie D. Adams

Research output: Contribution to journalArticle

Abstract

The results presented here reveal a novel platelet derived growth factor (PDGF) mediated early cellular event. Treatment of growth arrested Balb c3T3 fibroblasts with PDGF induces a specific and rapid modulation of a 64,000 Dalton (64 KD) protein preexisting in quiescent cells. The kinetics of 64 KD protein modulation indicate that, temporally, this PDGF mediated step lies between the membrane associated immediate events such as receptor autophosphorylation or ion mobilization and the earliest known transcriptional event, the activation of the proto-oncogene c-fos.

Original languageEnglish (US)
Pages (from-to)394-401
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume162
Issue number1
DOIs
StatePublished - Jul 14 1989
Externally publishedYes

Fingerprint

Platelet-Derived Growth Factor
Fibroblasts
Modulation
fos Genes
Early Ambulation
Proteins
Transcriptional Activation
Chemical activation
Ions
Membranes
Kinetics
Growth
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Rapid modulation of a 64 K Dalton fibroblast protein : a PDGF mediated early cellular event. / Singh, Jai Pal; Bonin, Paul D.; Adams, Lonnie D.

In: Biochemical and Biophysical Research Communications, Vol. 162, No. 1, 14.07.1989, p. 394-401.

Research output: Contribution to journalArticle

Singh, Jai Pal ; Bonin, Paul D. ; Adams, Lonnie D. / Rapid modulation of a 64 K Dalton fibroblast protein : a PDGF mediated early cellular event. In: Biochemical and Biophysical Research Communications. 1989 ; Vol. 162, No. 1. pp. 394-401.
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