Rapid-onset dystonia-parkinsonism in a second family

A. Brashear, D. DeLeon, S. B. Bressman, D. Thyagarajan, M. R. Farlow, W. B. Dobyns

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Abstract

Rapid-onset dystonia-parkinsonism (RDP), first described in a large Midwestern family, is now reported in a second, apparently unrelated, family in which four individuals have this same syndrome. All four developed sudden onset of dysarthria, dysphagia, severe dystonic spasms, bradykinesia, and postural instability over less than 1 hour to a few days. Three of the four had stable limb dystonia for several years preceding the onset of combined dystonia-parkinsonism. Treatment with levodopa/carbidopa provided little benefit. We propose diagnostic criteria for RDP and further define the spectrum of this unusual disease.

Original languageEnglish (US)
Pages (from-to)1066-1069
Number of pages4
JournalNeurology
Volume48
Issue number4
DOIs
StatePublished - Apr 1997

ASJC Scopus subject areas

  • Clinical Neurology

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    Brashear, A., DeLeon, D., Bressman, S. B., Thyagarajan, D., Farlow, M. R., & Dobyns, W. B. (1997). Rapid-onset dystonia-parkinsonism in a second family. Neurology, 48(4), 1066-1069. https://doi.org/10.1212/WNL.48.4.1066