Rapid progression of primary cutaneous gammadelta T-cell lymphoma with an initial indolent clinical presentation

Riley E. Alexander, Alden R. Webb, Mohammad Abuel-Haija, Magdalena Czader

Research output: Contribution to journalArticle

8 Scopus citations


Primary cutaneous gamma delta T-cell lymphoma (CGD-TCL) is a rare cutaneous T-cell lymphoma characterized by a rapidly progressive clinical course and a poor prognosis. We report a case of a 52-year-old man with a 10-year history of erythematous nodules and a rapid terminal progression diagnosed as CGD-TCL. Biopsies taken at the time of progression showed a dense lymphocytic infiltrate involving the subcutaneous adipose tissue and deep dermis. One of the biopsies displayed much more limited involvement by CGD-TCL that was nearly identical to the biopsies of the erythematous lesions 10 years before. In conclusion, this case demonstrates a case of CGD-TCL presenting as a longstanding indolent disease with a rapid terminal progression. The indolent clinical course and histological heterogeneity make diagnosing this entity during the initial stage extremely challenging. This case underscores a diverse clinical presentations and a need to consider CGD-TCL in patients showing subcutaneous lesions with an indolent clinical course.

Original languageEnglish (US)
Pages (from-to)839-842
Number of pages4
JournalAmerican Journal of Dermatopathology
Issue number10
StatePublished - Jan 1 2014



  • Cutaneous T-cell lymphoma
  • Lymphoma
  • Panniculitis
  • Primary cutaneous gamma delta T-cell lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology
  • Medicine(all)

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