Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X

Malgorzata Kamocka, Morris Pollard, Mark Suckow, Wojciech P. Mielicki, Elliot D. Rosen

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Two common procoagulant activities associated with tumors are tissue factor and cancer procoagulant (CP), an activator of coagulation factor X. We have identified a convenient source of CP in transplanted Lobund-Wistar rat PA3 prostate tumors. CP activity was purified from 5 independent transplanted prostate tumors by column chromatography. The protein activated factor X in the absence of TF and factor VII. An antihuman CP antibody recognized rat CP in an ELISA and inactivated CP activity in a chromogenic assay. Lobund-Wistar prostate tumors may provide a convenient animal model useful in determining the role of CP in cancer development.

Original languageEnglish (US)
Pages (from-to)282-286
Number of pages5
JournalComparative medicine
Volume58
Issue number3
StatePublished - Jun 1 2008

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

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