Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X

Malgorzata Kamocka, Morris Pollard, Mark Suckow, Wojciech P. Mielicki, Elliot Rosen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Two common procoagulant activities associated with tumors are tissue factor and cancer procoagulant (CP), an activator of coagulation factor X. We have identified a convenient source of CP in transplanted Lobund-Wistar rat PA3 prostate tumors. CP activity was purified from 5 independent transplanted prostate tumors by column chromatography. The protein activated factor X in the absence of TF and factor VII. An antihuman CP antibody recognized rat CP in an ELISA and inactivated CP activity in a chromogenic assay. Lobund-Wistar prostate tumors may provide a convenient animal model useful in determining the role of CP in cancer development.

Original languageEnglish
Pages (from-to)282-286
Number of pages5
JournalComparative Medicine
Volume58
Issue number3
StatePublished - Jun 2008

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cancer procoagulant
Factor X
prostatic neoplasms
coagulation
Rats
Tumors
Prostate
neoplasms
rats
Neoplasms
Chromogenics
Column chromatography
Factor VII
Factor Xa
Thromboplastin
Chromatography
Wistar Rats
Assays
Animals
Animal Models

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X. / Kamocka, Malgorzata; Pollard, Morris; Suckow, Mark; Mielicki, Wojciech P.; Rosen, Elliot.

In: Comparative Medicine, Vol. 58, No. 3, 06.2008, p. 282-286.

Research output: Contribution to journalArticle

Kamocka, Malgorzata ; Pollard, Morris ; Suckow, Mark ; Mielicki, Wojciech P. ; Rosen, Elliot. / Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X. In: Comparative Medicine. 2008 ; Vol. 58, No. 3. pp. 282-286.
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