Rational principles for immunoglobulin prophylaxis and therapy of neonatal infections

R. M. Kliegman, D. Clapp

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Immunotherapy was a common method of treating infectious diseases in the preantibiotic era. Serotherapy was a popular approach to serious infections and employed hyperimmune globulins harvested from various large animals. Such antisera needed to be administered early in the course of the disease and unfortunately was associated with significant risks of anaphylaxis and serum sickness. Because of the allergic risks associated with animal immunoglobulin preparations, the development of methods to isolate human immunoglobulins heralded a new era in immunotherapy. This article examines the uses of immunotherapy in the treatment of neonatal infections.

Original languageEnglish (US)
Pages (from-to)303-324
Number of pages22
JournalClinics in Perinatology
Volume18
Issue number2
StatePublished - 1991
Externally publishedYes

Fingerprint

Passive Immunization
Immunotherapy
Immunoglobulins
Infection
Serum Sickness
Globulins
Anaphylaxis
Communicable Diseases
Immune Sera
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Rational principles for immunoglobulin prophylaxis and therapy of neonatal infections. / Kliegman, R. M.; Clapp, D.

In: Clinics in Perinatology, Vol. 18, No. 2, 1991, p. 303-324.

Research output: Contribution to journalArticle

@article{ee84804b64aa4ea7bfa3e6b97864d209,
title = "Rational principles for immunoglobulin prophylaxis and therapy of neonatal infections",
abstract = "Immunotherapy was a common method of treating infectious diseases in the preantibiotic era. Serotherapy was a popular approach to serious infections and employed hyperimmune globulins harvested from various large animals. Such antisera needed to be administered early in the course of the disease and unfortunately was associated with significant risks of anaphylaxis and serum sickness. Because of the allergic risks associated with animal immunoglobulin preparations, the development of methods to isolate human immunoglobulins heralded a new era in immunotherapy. This article examines the uses of immunotherapy in the treatment of neonatal infections.",
author = "Kliegman, {R. M.} and D. Clapp",
year = "1991",
language = "English (US)",
volume = "18",
pages = "303--324",
journal = "Clinics in Perinatology",
issn = "0095-5108",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Rational principles for immunoglobulin prophylaxis and therapy of neonatal infections

AU - Kliegman, R. M.

AU - Clapp, D.

PY - 1991

Y1 - 1991

N2 - Immunotherapy was a common method of treating infectious diseases in the preantibiotic era. Serotherapy was a popular approach to serious infections and employed hyperimmune globulins harvested from various large animals. Such antisera needed to be administered early in the course of the disease and unfortunately was associated with significant risks of anaphylaxis and serum sickness. Because of the allergic risks associated with animal immunoglobulin preparations, the development of methods to isolate human immunoglobulins heralded a new era in immunotherapy. This article examines the uses of immunotherapy in the treatment of neonatal infections.

AB - Immunotherapy was a common method of treating infectious diseases in the preantibiotic era. Serotherapy was a popular approach to serious infections and employed hyperimmune globulins harvested from various large animals. Such antisera needed to be administered early in the course of the disease and unfortunately was associated with significant risks of anaphylaxis and serum sickness. Because of the allergic risks associated with animal immunoglobulin preparations, the development of methods to isolate human immunoglobulins heralded a new era in immunotherapy. This article examines the uses of immunotherapy in the treatment of neonatal infections.

UR - http://www.scopus.com/inward/record.url?scp=0025891554&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025891554&partnerID=8YFLogxK

M3 - Article

VL - 18

SP - 303

EP - 324

JO - Clinics in Perinatology

JF - Clinics in Perinatology

SN - 0095-5108

IS - 2

ER -