Rationale, design, and baseline characteristics of a community-based comparative effectiveness trial to prevent type 2 diabetes in economically disadvantaged adults: The RAPID Study

Ronald T. Ackermann, Emily A. Finch, Karen K. Schmidt, Helena M. Hoen, Laura M. Hays, David Marrero, Chandan Saha

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Reaching Out and Preventing Increases in Diabetes (RAPID) is a community-based randomized trial evaluating the comparative costs and effectiveness of a group-based adaption of the DPP lifestyle intervention developed and implemented in partnership with the YMCA. RAPID enrolled adult primary care patients, with BMI 24kg/m2 or higher and abnormal glucose metabolism (HbA1c 5.7-6.9% or fasting plasma glucose 100-125mg/dL). 509 participants were enrolled and randomized to one of two groups: standard clinical advice plus free-of-charge access to a group-based adaption of the DPP offered by the Y, versus standard clinical advice alone. Key outcomes for future analysis will include differences in body weight and other cardiovascular risk factors over a 24-month intervention period.At baseline, RAPID participants had a mean (SD) age of 51±12.1years, weight of 225.1±56.2lbs, and BMI of 36.9±8.6kg/m2. 70.7% were women, 57.2% were African American, 35.4% were non-Hispanic White, and 3.2% were Hispanic. Mean HbA1c was 6.05±0.34%. Additionally, 55.4% of participants had a baseline systolic blood pressure of ≥130mmHg, 33.1% had a total blood cholesterol exceeding 200mg/dL, and 74% reported a household income of <$25,000. The RAPID Study successfully randomized a large cohort of participants with a wide distribution of age, body weight, and race who are at high risk for developing type 2 diabetes.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalContemporary Clinical Trials
Volume37
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Vulnerable Populations
Type 2 Diabetes Mellitus
Body Weight
Blood Pressure
Glucose
Age Distribution
Hispanic Americans
African Americans
Cost-Benefit Analysis
Life Style
Fasting
Primary Health Care
Cholesterol
Weights and Measures

Keywords

  • Community research
  • Lifestyle intervention
  • Overweight/obesity
  • Pre-diabetes
  • Primary prevention
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Medicine(all)

Cite this

Rationale, design, and baseline characteristics of a community-based comparative effectiveness trial to prevent type 2 diabetes in economically disadvantaged adults : The RAPID Study. / Ackermann, Ronald T.; Finch, Emily A.; Schmidt, Karen K.; Hoen, Helena M.; Hays, Laura M.; Marrero, David; Saha, Chandan.

In: Contemporary Clinical Trials, Vol. 37, No. 1, 01.2014, p. 1-9.

Research output: Contribution to journalArticle

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