RB virus: a strain of Friend virus that produces a 'Friend virus-like' disease in Fν-2rr mice

Roy W. Geib, Mary Beth Seaward, Marcella L. Stevens, Lung Cho Chung Lung Cho, Manas Majumdar

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

RB virus is a newly derived strain of Friend virus that was adapted to produce a 'Friend-like' disease in mice that are genetically resistant to wild-type Friend virus. RB virus was produced by passing high titers of the wild-type Friend virus (Lilly-Steeves polycythemia-producing strain) through adult Fν-2rr mice. Titration of the defective spleen focus-forming virus indicated RB virus infected similar numbers of Fν-2ss or Fν-2rr target cells. Analysis of the spleens from mice infected with RB virus indicated that RB induced the early stage of Friend disease (erythroid proliferation) in both Fν-2rr and Fν-2ss mice. Fν-2ss mice infected with RB virus developed the classical Friend disease within 3 weeks. In contrast, the percentage of Fν-2rr mice developing the 'Friend-like' disease after infection with RB virus never exceeded 60%. The latency period of RBV in Fν-2rr mice was strain dependent. D2.R16 (Fν-2rr) developed the syndrome more rapidly than C57BL/6 (Fν-2rr). RB virus retained the capacity to transform erythroprogenitor cells from both Fν-2ss and Fν-2ss animals. Cells infected with RB virus consistently produced a modified SFFV envelope protein, gp48.

Original languageEnglish
Pages (from-to)161-173
Number of pages13
JournalVirus Research
Volume14
Issue number2
DOIs
StatePublished - 1989

Fingerprint

Friend murine leukemia virus
Virus Diseases
Viruses
Spleen Focus-Forming Viruses
Defective Viruses
Polycythemia
Spleen

Keywords

  • Friend virus
  • Mouse
  • Retrovirus
  • Spleen focus-forming virus Fv-2
  • Susceptibility

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Virology

Cite this

Geib, R. W., Seaward, M. B., Stevens, M. L., Chung Lung Cho, L. C., & Majumdar, M. (1989). RB virus: a strain of Friend virus that produces a 'Friend virus-like' disease in Fν-2rr mice. Virus Research, 14(2), 161-173. https://doi.org/10.1016/0168-1702(89)90036-1

RB virus : a strain of Friend virus that produces a 'Friend virus-like' disease in Fν-2rr mice. / Geib, Roy W.; Seaward, Mary Beth; Stevens, Marcella L.; Chung Lung Cho, Lung Cho; Majumdar, Manas.

In: Virus Research, Vol. 14, No. 2, 1989, p. 161-173.

Research output: Contribution to journalArticle

Geib, RW, Seaward, MB, Stevens, ML, Chung Lung Cho, LC & Majumdar, M 1989, 'RB virus: a strain of Friend virus that produces a 'Friend virus-like' disease in Fν-2rr mice', Virus Research, vol. 14, no. 2, pp. 161-173. https://doi.org/10.1016/0168-1702(89)90036-1
Geib, Roy W. ; Seaward, Mary Beth ; Stevens, Marcella L. ; Chung Lung Cho, Lung Cho ; Majumdar, Manas. / RB virus : a strain of Friend virus that produces a 'Friend virus-like' disease in Fν-2rr mice. In: Virus Research. 1989 ; Vol. 14, No. 2. pp. 161-173.
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