RB virus: a strain of Friend virus that produces a 'Friend virus-like' disease in Fν-2rr mice

Roy W. Geib, Mary Beth Seaward, Marcella L. Stevens, Lung Cho Chung Lung Cho, Manas Majumdar

Research output: Contribution to journalArticle

3 Scopus citations


RB virus is a newly derived strain of Friend virus that was adapted to produce a 'Friend-like' disease in mice that are genetically resistant to wild-type Friend virus. RB virus was produced by passing high titers of the wild-type Friend virus (Lilly-Steeves polycythemia-producing strain) through adult Fν-2rr mice. Titration of the defective spleen focus-forming virus indicated RB virus infected similar numbers of Fν-2ss or Fν-2rr target cells. Analysis of the spleens from mice infected with RB virus indicated that RB induced the early stage of Friend disease (erythroid proliferation) in both Fν-2rr and Fν-2ss mice. Fν-2ss mice infected with RB virus developed the classical Friend disease within 3 weeks. In contrast, the percentage of Fν-2rr mice developing the 'Friend-like' disease after infection with RB virus never exceeded 60%. The latency period of RBV in Fν-2rr mice was strain dependent. D2.R16 (Fν-2rr) developed the syndrome more rapidly than C57BL/6 (Fν-2rr). RB virus retained the capacity to transform erythroprogenitor cells from both Fν-2ss and Fν-2ss animals. Cells infected with RB virus consistently produced a modified SFFV envelope protein, gp48.

Original languageEnglish (US)
Pages (from-to)161-173
Number of pages13
JournalVirus Research
Issue number2
StatePublished - Oct 1989



  • Friend virus
  • Mouse
  • Retrovirus
  • Spleen focus-forming virus Fv-2
  • Susceptibility

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Virology

Cite this

Geib, R. W., Seaward, M. B., Stevens, M. L., Chung Lung Cho, L. C., & Majumdar, M. (1989). RB virus: a strain of Friend virus that produces a 'Friend virus-like' disease in Fν-2rr mice. Virus Research, 14(2), 161-173. https://doi.org/10.1016/0168-1702(89)90036-1