RB virus is a newly derived strain of Friend virus that was adapted to produce a 'Friend-like' disease in mice that are genetically resistant to wild-type Friend virus. RB virus was produced by passing high titers of the wild-type Friend virus (Lilly-Steeves polycythemia-producing strain) through adult Fν-2rr mice. Titration of the defective spleen focus-forming virus indicated RB virus infected similar numbers of Fν-2ss or Fν-2rr target cells. Analysis of the spleens from mice infected with RB virus indicated that RB induced the early stage of Friend disease (erythroid proliferation) in both Fν-2rr and Fν-2ss mice. Fν-2ss mice infected with RB virus developed the classical Friend disease within 3 weeks. In contrast, the percentage of Fν-2rr mice developing the 'Friend-like' disease after infection with RB virus never exceeded 60%. The latency period of RBV in Fν-2rr mice was strain dependent. D2.R16 (Fν-2rr) developed the syndrome more rapidly than C57BL/6 (Fν-2rr). RB virus retained the capacity to transform erythroprogenitor cells from both Fν-2ss and Fν-2ss animals. Cells infected with RB virus consistently produced a modified SFFV envelope protein, gp48.
- Friend virus
- Spleen focus-forming virus Fv-2
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology