Real-time intravascular photoacoustic-ultrasound imaging of lipid-laden plaque at speed of video-rate level

Jie Hui, Yingchun Cao, Yi Zhang, Ayeeshik Kole, Pu Wang, Guangli Yu, Gregory Eakins, Michael Sturek, Weibiao Chen, Ji Xin Cheng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Intravascular photoacoustic-ultrasound (IVPA-US) imaging is an emerging hybrid modality for the detection of lipidladen plaques by providing simultaneous morphological and lipid-specific chemical information of an artery wall. The clinical utility of IVPA-US technology requires real-time imaging and display at speed of video-rate level. Here, we demonstrate a compact and portable IVPA-US system capable of imaging at up to 25 frames per second in real-time display mode. This unprecedented imaging speed was achieved by concurrent innovations in excitation laser source, rotary joint assembly, 1 mm IVPA-US catheter, differentiated A-line strategy, and real-time image processing and display algorithms. By imaging pulsatile motion at different imaging speeds, 16 frames per second was deemed to be adequate to suppress motion artifacts from cardiac pulsation for in vivo applications. Our lateral resolution results further verified the number of A-lines used for a cross-sectional IVPA image reconstruction. The translational capability of this system for the detection of lipid-laden plaques was validated by ex vivo imaging of an atherosclerotic human coronary artery at 16 frames per second, which showed strong correlation to gold-standard histopathology.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2017
EditorsAlexander A. Oraevsky, Lihong V. Wang
PublisherSPIE
ISBN (Electronic)9781510605695
DOIs
StatePublished - Jan 1 2017
EventPhotons Plus Ultrasound: Imaging and Sensing 2017 - San Francisco, United States
Duration: Jan 29 2017Feb 1 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10064
ISSN (Print)1605-7422

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2017
CountryUnited States
CitySan Francisco
Period1/29/172/1/17

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Keywords

  • Atherosclerosis
  • Intravascular imaging
  • Lipid
  • Overtone absorption
  • Photoacoustic
  • Real-time
  • Video-rate imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Hui, J., Cao, Y., Zhang, Y., Kole, A., Wang, P., Yu, G., Eakins, G., Sturek, M., Chen, W., & Cheng, J. X. (2017). Real-time intravascular photoacoustic-ultrasound imaging of lipid-laden plaque at speed of video-rate level. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2017 [100640T] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10064). SPIE. https://doi.org/10.1117/12.2251511