Reasons for nonadherence to tamoxifen and aromatase inhibitors for the treatment of breast cancer: A literature review

Suhila Sawesi, Janet Carpenter, Josette Jones

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Despite improved breast cancer survival rates with the use of tamoxifen and aromatase inhibitors, patients remain at risk for cancer recurrence and mortality because of nonadherence to medication. The objective of this review was to identify factors associated with nonadherence among patients with breast cancer. Electronic databases were searched for studies, and potentially relevant studies were retrieved and assessed for eligibility. Potential factors associated with nonadherence were identified, and they included patient-related factors (e.g., patient beliefs and knowledge, fear of adverse effects, forgetfulness, smoking, age, race), therapy-related factors (e.g., duration, side effects, additional prescribed medications, treatment interfering with lifestyle), healthcare system factors (e.g., patient/provider relationships), socioeconomic factors (e.g., medication costs, burden, scheduling problems, religion, marital status), and disease-related factors (e.g., comorbidities, stage of breast cancer). Those findings highlight the need for development of interventions to promote long-term adherence in patients with breast cancer.

Original languageEnglish
JournalClinical Journal of Oncology Nursing
Volume18
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Aromatase Inhibitors
Tamoxifen
Breast Neoplasms
Patient Compliance
Medication Adherence
Marital Status
Religion
Therapeutics
Fear
Life Style
Comorbidity
Survival Rate
Smoking
Databases
Delivery of Health Care
Costs and Cost Analysis
Recurrence
Mortality
Neoplasms

Keywords

  • Aromatase inhibitors
  • Breast cancer
  • Chemotherapy
  • Informatics and electronic health records
  • Patient/public education
  • Tamoxifen

ASJC Scopus subject areas

  • Oncology(nursing)
  • Oncology
  • Medicine(all)

Cite this

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abstract = "Despite improved breast cancer survival rates with the use of tamoxifen and aromatase inhibitors, patients remain at risk for cancer recurrence and mortality because of nonadherence to medication. The objective of this review was to identify factors associated with nonadherence among patients with breast cancer. Electronic databases were searched for studies, and potentially relevant studies were retrieved and assessed for eligibility. Potential factors associated with nonadherence were identified, and they included patient-related factors (e.g., patient beliefs and knowledge, fear of adverse effects, forgetfulness, smoking, age, race), therapy-related factors (e.g., duration, side effects, additional prescribed medications, treatment interfering with lifestyle), healthcare system factors (e.g., patient/provider relationships), socioeconomic factors (e.g., medication costs, burden, scheduling problems, religion, marital status), and disease-related factors (e.g., comorbidities, stage of breast cancer). Those findings highlight the need for development of interventions to promote long-term adherence in patients with breast cancer.",
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