Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip

Bumsoo Han, Chunjing Qu, Kinam Park, Stephen F. Konieczny, Murray Korc

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Targeted delivery aims to selectively distribute drugs to targeted tumor tissues but not to healthy tissues. This can address many clinical challenges by maximizing the efficacy but minimizing the toxicity of anti-cancer drugs. However, a complex tumor microenvironment poses various barriers hindering the transport of drugs and drug delivery systems. New tumor models that allow for the systematic study of these complex environments are highly desired to provide reliable test beds to develop drug delivery systems for targeted delivery. Recently, research efforts have yielded new in vitro tumor models, the so called tumor-microenvironment-on-chip, that recapitulate certain characteristics of the tumor microenvironment. These new models show benefits over other conventional tumor models, and have the potential to accelerate drug discovery and enable precision medicine. However, further research is warranted to overcome their limitations and to properly interpret the data obtained from these models. In this article, key features of the in vivo tumor microenvironment that are relevant to drug transport processes for targeted delivery were discussed, and the current status and challenges for developing in vitro transport model systems were reviewed.

Original languageEnglish (US)
JournalCancer Letters
DOIs
StateAccepted/In press - 2016

Fingerprint

Tumor Microenvironment
Pharmaceutical Preparations
Drug Delivery Systems
Neoplasms
Precision Medicine
Drug Discovery
Research

Keywords

  • Drug transport
  • Microfluidics
  • Nanoparticles
  • Stromal tissue
  • Targeted delivery

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip. / Han, Bumsoo; Qu, Chunjing; Park, Kinam; Konieczny, Stephen F.; Korc, Murray.

In: Cancer Letters, 2016.

Research output: Contribution to journalArticle

Han, Bumsoo ; Qu, Chunjing ; Park, Kinam ; Konieczny, Stephen F. ; Korc, Murray. / Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip. In: Cancer Letters. 2016.
@article{d810b9bf026246039ce05a618ce44c7d,
title = "Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip",
abstract = "Targeted delivery aims to selectively distribute drugs to targeted tumor tissues but not to healthy tissues. This can address many clinical challenges by maximizing the efficacy but minimizing the toxicity of anti-cancer drugs. However, a complex tumor microenvironment poses various barriers hindering the transport of drugs and drug delivery systems. New tumor models that allow for the systematic study of these complex environments are highly desired to provide reliable test beds to develop drug delivery systems for targeted delivery. Recently, research efforts have yielded new in vitro tumor models, the so called tumor-microenvironment-on-chip, that recapitulate certain characteristics of the tumor microenvironment. These new models show benefits over other conventional tumor models, and have the potential to accelerate drug discovery and enable precision medicine. However, further research is warranted to overcome their limitations and to properly interpret the data obtained from these models. In this article, key features of the in vivo tumor microenvironment that are relevant to drug transport processes for targeted delivery were discussed, and the current status and challenges for developing in vitro transport model systems were reviewed.",
keywords = "Drug transport, Microfluidics, Nanoparticles, Stromal tissue, Targeted delivery",
author = "Bumsoo Han and Chunjing Qu and Kinam Park and Konieczny, {Stephen F.} and Murray Korc",
year = "2016",
doi = "10.1016/j.canlet.2015.12.003",
language = "English (US)",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip

AU - Han, Bumsoo

AU - Qu, Chunjing

AU - Park, Kinam

AU - Konieczny, Stephen F.

AU - Korc, Murray

PY - 2016

Y1 - 2016

N2 - Targeted delivery aims to selectively distribute drugs to targeted tumor tissues but not to healthy tissues. This can address many clinical challenges by maximizing the efficacy but minimizing the toxicity of anti-cancer drugs. However, a complex tumor microenvironment poses various barriers hindering the transport of drugs and drug delivery systems. New tumor models that allow for the systematic study of these complex environments are highly desired to provide reliable test beds to develop drug delivery systems for targeted delivery. Recently, research efforts have yielded new in vitro tumor models, the so called tumor-microenvironment-on-chip, that recapitulate certain characteristics of the tumor microenvironment. These new models show benefits over other conventional tumor models, and have the potential to accelerate drug discovery and enable precision medicine. However, further research is warranted to overcome their limitations and to properly interpret the data obtained from these models. In this article, key features of the in vivo tumor microenvironment that are relevant to drug transport processes for targeted delivery were discussed, and the current status and challenges for developing in vitro transport model systems were reviewed.

AB - Targeted delivery aims to selectively distribute drugs to targeted tumor tissues but not to healthy tissues. This can address many clinical challenges by maximizing the efficacy but minimizing the toxicity of anti-cancer drugs. However, a complex tumor microenvironment poses various barriers hindering the transport of drugs and drug delivery systems. New tumor models that allow for the systematic study of these complex environments are highly desired to provide reliable test beds to develop drug delivery systems for targeted delivery. Recently, research efforts have yielded new in vitro tumor models, the so called tumor-microenvironment-on-chip, that recapitulate certain characteristics of the tumor microenvironment. These new models show benefits over other conventional tumor models, and have the potential to accelerate drug discovery and enable precision medicine. However, further research is warranted to overcome their limitations and to properly interpret the data obtained from these models. In this article, key features of the in vivo tumor microenvironment that are relevant to drug transport processes for targeted delivery were discussed, and the current status and challenges for developing in vitro transport model systems were reviewed.

KW - Drug transport

KW - Microfluidics

KW - Nanoparticles

KW - Stromal tissue

KW - Targeted delivery

UR - http://www.scopus.com/inward/record.url?scp=84966606328&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84966606328&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2015.12.003

DO - 10.1016/j.canlet.2015.12.003

M3 - Article

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

ER -