Recent advances in genome editing and creation of genetically modified pigs

James R. Butler, Joseph M. Ladowski, Gregory R. Martens, Matthew Tector, A. Joseph Tector

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

The field of xenotransplantation is benefiting greatly from recent advances in genetic engineering. The efficiency and pace with which new model animals are being created has dramatically sped progress towards clinical relevance. Endonuclease-driven genome editing now allows for the efficient generation of targeted genetic alterations. Herein we review the available methods of genetic engineering that have been successfully employed to create genetically modified pigs.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalInternational Journal of Surgery
Volume23
DOIs
StatePublished - Nov 1 2015

Keywords

  • Endonuclease
  • Homologous recombination
  • Off-target
  • TALEN CRISPR/Cas9
  • Zinc finger nuclease

ASJC Scopus subject areas

  • Surgery

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    Butler, J. R., Ladowski, J. M., Martens, G. R., Tector, M., & Tector, A. J. (2015). Recent advances in genome editing and creation of genetically modified pigs. International Journal of Surgery, 23, 217-222. https://doi.org/10.1016/j.ijsu.2015.07.684