Recent advances in renal phosphate handling

Emily G. Farrow, Kenneth E. White

Research output: Contribution to journalReview article

72 Citations (Scopus)

Abstract

Phosphate is critical for the maintenance of skeletal integrity, is a necessary component of important biomolecules, and is central to signal transduction and cell metabolism. It is becoming clear that endocrine communication between the skeleton, kidney, and the intestine is involved in maintaining appropriate serum phosphate concentrations, and that the kidney is the primary site for minute-to-minute regulation of phosphate levels. The identification of genetic alterations in Mendelian disorders of hypophosphatemia and hyperphosphatemia has led to the isolation of novel genes and the identification of new roles for existing proteins-such as fibroblast growth factor 23 and its processing systems, the co-receptor α-klotho, and phosphate transporters-in the control of renal phosphate handling. Recent findings also indicate that fibroblast growth factor 23 has feedback mechanisms involving parathyroid hormone and vitamin D that control phosphate homeostasis. This Review will highlight genetic, in vitro and in vivo findings, and will discuss how these clinical and experimental discoveries have uncovered novel aspects of renal phosphate handling and opened new research and therapeutic avenues.

Original languageEnglish (US)
Pages (from-to)207-217
Number of pages11
JournalNature Reviews Nephrology
Volume6
Issue number4
DOIs
StatePublished - Apr 1 2010

Fingerprint

Phosphates
Kidney
Phosphate Transport Proteins
Therapeutic Human Experimentation
Hyperphosphatemia
Hypophosphatemia
Parathyroid Hormone
Skeleton
Vitamin D
Intestines
Signal Transduction
Homeostasis
Maintenance
Serum
Genes
Proteins
fibroblast growth factor 23

ASJC Scopus subject areas

  • Nephrology

Cite this

Recent advances in renal phosphate handling. / Farrow, Emily G.; White, Kenneth E.

In: Nature Reviews Nephrology, Vol. 6, No. 4, 01.04.2010, p. 207-217.

Research output: Contribution to journalReview article

Farrow, Emily G. ; White, Kenneth E. / Recent advances in renal phosphate handling. In: Nature Reviews Nephrology. 2010 ; Vol. 6, No. 4. pp. 207-217.
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