Recent advances in the development of GTR/GBR membranes for periodontal regeneration - A materials perspective

Marco C. Bottino, Vinoy Thomas, Gudrun Schmidt, Yogesh K. Vohra, Tien Min Gabriel Chu, Michael J. Kowolik, Gregg M. Janowski

Research output: Contribution to journalReview article

308 Scopus citations


Periodontitis is a major chronic inflammatory disorder that can lead to the destruction of the periodontal tissues and, ultimately, tooth loss. To date, flap debridement and/or flap curettage and periodontal regenerative therapy with membranes and bone grafting materials have been employed with distinct levels of clinical success. Current resorbable and non-resorbable membranes act as a physical barrier to avoid connective and epithelial tissue down-growth into the defect, favoring the regeneration of periodontal tissues. These conventional membranes possess many structural, mechanical, and bio-functional limitations and the "ideal" membrane for use in periodontal regenerative therapy has yet to be developed. Based on a graded-biomaterials approach, we have hypothesized that the next-generation of guided tissue and guided bone regeneration (GTR/GBR) membranes for periodontal tissue engineering will be a biologically active, spatially designed and functionally graded nanofibrous biomaterial that closely mimics the native extra-cellular matrix (ECM). Objective: This review is presented in three major parts, including (1) a brief overview of the periodontium and its pathological conditions, (2) currently employed therapeutics used to regenerate the distinct periodontal tissues, and (3) a review of commercially available GTR/GBR membranes as well as the recent advances on the processing and characterization of GTR/GBR membranes from a materials perspective. Significance: Studies of spatially designed and functionally graded membranes (FGM) and in vitro antibacterial/cell-related research are addressed. Finally, as a future outlook, the use of hydrogels in combination with scaffold materials is highlighted as a promising approach for periodontal tissue engineering.

Original languageEnglish (US)
Pages (from-to)703-721
Number of pages19
JournalDental Materials
Issue number7
StatePublished - Jul 1 2012


  • Drug delivery
  • Electrospinning
  • Guided tissue regeneration
  • Hydrogels
  • Hydroxyapatite
  • Membranes
  • Periodontal regeneration
  • Periodontitis
  • Scaffolds

ASJC Scopus subject areas

  • Dentistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Medicine(all)

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