Recent advances in the understanding of polycystic kidney disease

Robert Bacallao, Frank A. Carone

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Polycystic kidney disease is characterized by localized autonomous cellular proliferation, compartmentalized fluid accumulation within the cysts, and intraparenchymal fibrosis of the kidney. The clinical features include renal failure, liver cysts, and vascular and cardiac valve abnormalities. Recent developments have extended our understanding of cyst formation, fluid secretion, and the genetics of polycystic kidney disease. Two causal genes for polycystic kidney disease, PKD1 and PKD2, that are responsible for greater than 95% of cases of autosomal dominant polycystic kidney disease, have been identified and sequenced. The mechanisms of cystogenesis are being uncovered and the phenotypic features of cystic epithelial cells are being discovered. This review describes recent advances made in the molecular biology of the genetic causes of polycystic kidney disease. The mechanistic details of cystogenesis are discussed and contrasted with the paradigms that guide current experimental approaches.

Original languageEnglish
Pages (from-to)377-383
Number of pages7
JournalCurrent Opinion in Nephrology and Hypertension
Volume6
Issue number4
StatePublished - 1997

Fingerprint

Polycystic Kidney Diseases
Cysts
Molecular Biology
Cyst Fluid
Autosomal Dominant Polycystic Kidney
Fluids and Secretions
Heart Valves
Renal Insufficiency
Blood Vessels
Fibrosis
Epithelial Cells
Cell Proliferation
Kidney
Liver
Genes

ASJC Scopus subject areas

  • Nephrology
  • Internal Medicine

Cite this

Recent advances in the understanding of polycystic kidney disease. / Bacallao, Robert; Carone, Frank A.

In: Current Opinion in Nephrology and Hypertension, Vol. 6, No. 4, 1997, p. 377-383.

Research output: Contribution to journalArticle

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