Recent Advances in Understanding Bisphosphonate Effects on Bone Mechanical Properties

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Purpose of the Review: Bisphosphonates have well-established effects on suppressing bone resorption and slowing bone loss, yet the effects on bone mechanical properties are less clear. We review recent data from pre-clinical and clinical experiments that assessed mechanical properties of bisphosphonate-treated specimens. Recent Findings: Pre-clinical work has utilized new techniques to show reduced fatigue life and transfer of stress from the mineral to collagen. Several notable studies have examined mechanical properties of tissue from patients treated with bisphosphonates with mixed results. Pre-clinical data suggest effects on mechanics may be independent of remodeling suppression. Summary: The direct effect of bisphosphonates on bone mechanics remains unclear but recent work has set a solid foundation for the coming years.

Original languageEnglish (US)
Pages (from-to)198-204
Number of pages7
JournalCurrent Osteoporosis Reports
Volume16
Issue number2
DOIs
StatePublished - Apr 1 2018

Fingerprint

Diphosphonates
Bone and Bones
Mechanics
Bone Resorption
Psychological Stress
Fatigue
Minerals
Collagen

Keywords

  • Anti-remodeling
  • Atypical fracture
  • Biomechanics
  • Remodeling suppression
  • Zoledronate

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Recent Advances in Understanding Bisphosphonate Effects on Bone Mechanical Properties. / Allen, Matthew.

In: Current Osteoporosis Reports, Vol. 16, No. 2, 01.04.2018, p. 198-204.

Research output: Contribution to journalReview article

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