The second most common disorder of bone after osteoporosis, Paget's disease can affect any area of the skeleton, although the axial skeleton is most often involved. Skeletal deformity and pain are the most common symptoms at presentation. The most useful laboratory diagnostic tests are serum alkaline phosphatase and urinary pyridinoline. An elevated alkaline phosphatase value should be followed by a bone scan, which can demonstrate early disease in a patient who has a normal radiographic evaluation. Bisphosphonates are standard therapy for most patients. Osteoclasts have a central role in Paget's disease and are increased in size and number in affected patients. The etiology of the disease remains uncertain. Several lines of evidence suggest involvement of a viral infection, possibly in concert with a genetic predisposition for increased osteoclastic activity.
|Original language||English (US)|
|Number of pages||7|
|Journal||Advanced Studies in Medicine|
|State||Published - May 1 2003|
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