Recent developments in Paget's disease

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The second most common disorder of bone after osteoporosis, Paget's disease can affect any area of the skeleton, although the axial skeleton is most often involved. Skeletal deformity and pain are the most common symptoms at presentation. The most useful laboratory diagnostic tests are serum alkaline phosphatase and urinary pyridinoline. An elevated alkaline phosphatase value should be followed by a bone scan, which can demonstrate early disease in a patient who has a normal radiographic evaluation. Bisphosphonates are standard therapy for most patients. Osteoclasts have a central role in Paget's disease and are increased in size and number in affected patients. The etiology of the disease remains uncertain. Several lines of evidence suggest involvement of a viral infection, possibly in concert with a genetic predisposition for increased osteoclastic activity.

Original languageEnglish (US)
Pages (from-to)286-292
Number of pages7
JournalAdvanced Studies in Medicine
Volume3
Issue number5
StatePublished - May 2003
Externally publishedYes

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Skeleton
Alkaline Phosphatase
Bone and Bones
Diphosphonates
Osteoclasts
Virus Diseases
Genetic Predisposition to Disease
Routine Diagnostic Tests
Osteoporosis
Pain
Serum
Therapeutics
pyridinoline

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Recent developments in Paget's disease. / Roodman, G. David.

In: Advanced Studies in Medicine, Vol. 3, No. 5, 05.2003, p. 286-292.

Research output: Contribution to journalArticle

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