Receptor-mediated targeting of 67Ga-deferoxamine-folate to folate- receptor-positive human KB tumor xenografts

Carla J. Mathias, Susan Wang, Philip S. Low, David J. Waters, Mark A. Green

Research output: Contribution to journalArticle

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Abstract

The radiochemical synthesis and stability of 67Ga-deferoxamine-folate ([67Ga]Ga-DF-Folate) were examined as a function of DF-Folate concentration. Optimal labeling occurred at DF-Folate concentrations 22.5 μg/mL. To define the possible biological significance of variations in product formulation, the biodistribution of [67Ga]Ga-DF-Folate was examined as a function of administered deferoxamine-folate dose in an athymic mouse KB tumor model. The folate-receptor-positive KB tumors were found to concentrate the 67Ga radiolabel in a dose-dependent fashion, consistent with saturable involvement of the folate receptor in mediating tumor accumulation of the radiopharmaceutical.

Original languageEnglish (US)
Pages (from-to)23-25
Number of pages3
JournalNuclear Medicine and Biology
Volume26
Issue number1
DOIs
StatePublished - Jan 1 1999

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Keywords

  • Folate receptor
  • Ga-Deferoxamine-folate
  • Tumor-targeting

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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