Receptor-mediated targeting of 67Ga-deferoxamine-folate to folate- receptor-positive human KB tumor xenografts

Carla J. Mathias, Susan Wang, Philip S. Low, David J. Waters, Mark Green

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The radiochemical synthesis and stability of 67Ga-deferoxamine-folate ([67Ga]Ga-DF-Folate) were examined as a function of DF-Folate concentration. Optimal labeling occurred at DF-Folate concentrations 22.5 μg/mL. To define the possible biological significance of variations in product formulation, the biodistribution of [67Ga]Ga-DF-Folate was examined as a function of administered deferoxamine-folate dose in an athymic mouse KB tumor model. The folate-receptor-positive KB tumors were found to concentrate the 67Ga radiolabel in a dose-dependent fashion, consistent with saturable involvement of the folate receptor in mediating tumor accumulation of the radiopharmaceutical.

Original languageEnglish (US)
Pages (from-to)23-25
Number of pages3
JournalNuclear Medicine and Biology
Volume26
Issue number1
DOIs
StatePublished - Jan 1999
Externally publishedYes

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Deferoxamine
Folic Acid
Heterografts
Neoplasms
Radiopharmaceuticals
Nude Mice

Keywords

  • Ga-Deferoxamine-folate
  • Folate receptor
  • Tumor-targeting

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Receptor-mediated targeting of 67Ga-deferoxamine-folate to folate- receptor-positive human KB tumor xenografts. / Mathias, Carla J.; Wang, Susan; Low, Philip S.; Waters, David J.; Green, Mark.

In: Nuclear Medicine and Biology, Vol. 26, No. 1, 01.1999, p. 23-25.

Research output: Contribution to journalArticle

Mathias, Carla J. ; Wang, Susan ; Low, Philip S. ; Waters, David J. ; Green, Mark. / Receptor-mediated targeting of 67Ga-deferoxamine-folate to folate- receptor-positive human KB tumor xenografts. In: Nuclear Medicine and Biology. 1999 ; Vol. 26, No. 1. pp. 23-25.
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