Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism

Arpana Agrawal, Rebecca Tillman, Richard A. Grucza, Elliot C. Nelson, Vivia V. McCutcheon, Lauren Few, Kenneth R. Conner, Michael T. Lynskey, Danielle M. Dick, Howard Edenberg, Victor M. Hesselbrock, John R. Kramer, Samuel Kuperman, John Nurnberger, Marc A. Schuckit, Bernice Porjesz, Kathleen K. Bucholz

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background Substance use and misuse and suicidal thoughts and behaviors tend to co-occur. The purpose of this study was to examine whether (a) suicidal ideation and attempt are related to onset of alcohol, nicotine and cannabis use and dependence; (b) early use of alcohol, nicotine and cannabis is associated with onset of suicidal ideation and attempt; and (c) whether these associations persist while controlling for covariates, such as family history of alcohol problems, major depression and other internalizing and externalizing disorders. Methods The prospective cohort of the Collaborative Study of the Genetics of Alcoholism (COGA; N=3277) was used. Cross-sectional and discrete time logistic regression (i.e. survival) analyses examined associations between suicidal ideation and attempt and onset of alcohol, nicotine and cannabis use and dependence. Survival models also examined whether individual early substance use was related to onset of ideation and attempt. Results Ideation was related to 0.71–0.77 odds of onset of subsequent alcohol, nicotine and cannabis use. Attempt was associated with 1.44–1.61 odds of later alcohol, nicotine and cannabis dependence, even after accounting for covariates. Evidence for early substance use being related to subsequent onset of ideation or attempt was limited. Several sex and race differences emerged. Limitations The sample was ascertained for family history of alcoholism; not all participants had been followed up allowing for censored observations; reporting bias. Conclusion Suicide attempts are associated with increased likelihood of onset of substance dependence.

Original languageEnglish (US)
Pages (from-to)96-104
Number of pages9
JournalJournal of Affective Disorders
Volume213
DOIs
StatePublished - Apr 15 2017

Fingerprint

Suicidal Ideation
Suicide
Alcoholism
Substance-Related Disorders
Marijuana Abuse
Nicotine
Alcohols
Cannabis
Tobacco Use Disorder
Survival Analysis
Sex Characteristics
Cohort Studies
Logistic Models
Depression

Keywords

  • Alcohol
  • Attempt
  • Cannabis
  • COGA
  • Ideation
  • Nicotine
  • Suicide

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism. / Agrawal, Arpana; Tillman, Rebecca; Grucza, Richard A.; Nelson, Elliot C.; McCutcheon, Vivia V.; Few, Lauren; Conner, Kenneth R.; Lynskey, Michael T.; Dick, Danielle M.; Edenberg, Howard; Hesselbrock, Victor M.; Kramer, John R.; Kuperman, Samuel; Nurnberger, John; Schuckit, Marc A.; Porjesz, Bernice; Bucholz, Kathleen K.

In: Journal of Affective Disorders, Vol. 213, 15.04.2017, p. 96-104.

Research output: Contribution to journalArticle

Agrawal, A, Tillman, R, Grucza, RA, Nelson, EC, McCutcheon, VV, Few, L, Conner, KR, Lynskey, MT, Dick, DM, Edenberg, H, Hesselbrock, VM, Kramer, JR, Kuperman, S, Nurnberger, J, Schuckit, MA, Porjesz, B & Bucholz, KK 2017, 'Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism', Journal of Affective Disorders, vol. 213, pp. 96-104. https://doi.org/10.1016/j.jad.2016.12.060
Agrawal, Arpana ; Tillman, Rebecca ; Grucza, Richard A. ; Nelson, Elliot C. ; McCutcheon, Vivia V. ; Few, Lauren ; Conner, Kenneth R. ; Lynskey, Michael T. ; Dick, Danielle M. ; Edenberg, Howard ; Hesselbrock, Victor M. ; Kramer, John R. ; Kuperman, Samuel ; Nurnberger, John ; Schuckit, Marc A. ; Porjesz, Bernice ; Bucholz, Kathleen K. / Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism. In: Journal of Affective Disorders. 2017 ; Vol. 213. pp. 96-104.
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abstract = "Background Substance use and misuse and suicidal thoughts and behaviors tend to co-occur. The purpose of this study was to examine whether (a) suicidal ideation and attempt are related to onset of alcohol, nicotine and cannabis use and dependence; (b) early use of alcohol, nicotine and cannabis is associated with onset of suicidal ideation and attempt; and (c) whether these associations persist while controlling for covariates, such as family history of alcohol problems, major depression and other internalizing and externalizing disorders. Methods The prospective cohort of the Collaborative Study of the Genetics of Alcoholism (COGA; N=3277) was used. Cross-sectional and discrete time logistic regression (i.e. survival) analyses examined associations between suicidal ideation and attempt and onset of alcohol, nicotine and cannabis use and dependence. Survival models also examined whether individual early substance use was related to onset of ideation and attempt. Results Ideation was related to 0.71–0.77 odds of onset of subsequent alcohol, nicotine and cannabis use. Attempt was associated with 1.44–1.61 odds of later alcohol, nicotine and cannabis dependence, even after accounting for covariates. Evidence for early substance use being related to subsequent onset of ideation or attempt was limited. Several sex and race differences emerged. Limitations The sample was ascertained for family history of alcoholism; not all participants had been followed up allowing for censored observations; reporting bias. Conclusion Suicide attempts are associated with increased likelihood of onset of substance dependence.",
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T1 - Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism

AU - Agrawal, Arpana

AU - Tillman, Rebecca

AU - Grucza, Richard A.

AU - Nelson, Elliot C.

AU - McCutcheon, Vivia V.

AU - Few, Lauren

AU - Conner, Kenneth R.

AU - Lynskey, Michael T.

AU - Dick, Danielle M.

AU - Edenberg, Howard

AU - Hesselbrock, Victor M.

AU - Kramer, John R.

AU - Kuperman, Samuel

AU - Nurnberger, John

AU - Schuckit, Marc A.

AU - Porjesz, Bernice

AU - Bucholz, Kathleen K.

PY - 2017/4/15

Y1 - 2017/4/15

N2 - Background Substance use and misuse and suicidal thoughts and behaviors tend to co-occur. The purpose of this study was to examine whether (a) suicidal ideation and attempt are related to onset of alcohol, nicotine and cannabis use and dependence; (b) early use of alcohol, nicotine and cannabis is associated with onset of suicidal ideation and attempt; and (c) whether these associations persist while controlling for covariates, such as family history of alcohol problems, major depression and other internalizing and externalizing disorders. Methods The prospective cohort of the Collaborative Study of the Genetics of Alcoholism (COGA; N=3277) was used. Cross-sectional and discrete time logistic regression (i.e. survival) analyses examined associations between suicidal ideation and attempt and onset of alcohol, nicotine and cannabis use and dependence. Survival models also examined whether individual early substance use was related to onset of ideation and attempt. Results Ideation was related to 0.71–0.77 odds of onset of subsequent alcohol, nicotine and cannabis use. Attempt was associated with 1.44–1.61 odds of later alcohol, nicotine and cannabis dependence, even after accounting for covariates. Evidence for early substance use being related to subsequent onset of ideation or attempt was limited. Several sex and race differences emerged. Limitations The sample was ascertained for family history of alcoholism; not all participants had been followed up allowing for censored observations; reporting bias. Conclusion Suicide attempts are associated with increased likelihood of onset of substance dependence.

AB - Background Substance use and misuse and suicidal thoughts and behaviors tend to co-occur. The purpose of this study was to examine whether (a) suicidal ideation and attempt are related to onset of alcohol, nicotine and cannabis use and dependence; (b) early use of alcohol, nicotine and cannabis is associated with onset of suicidal ideation and attempt; and (c) whether these associations persist while controlling for covariates, such as family history of alcohol problems, major depression and other internalizing and externalizing disorders. Methods The prospective cohort of the Collaborative Study of the Genetics of Alcoholism (COGA; N=3277) was used. Cross-sectional and discrete time logistic regression (i.e. survival) analyses examined associations between suicidal ideation and attempt and onset of alcohol, nicotine and cannabis use and dependence. Survival models also examined whether individual early substance use was related to onset of ideation and attempt. Results Ideation was related to 0.71–0.77 odds of onset of subsequent alcohol, nicotine and cannabis use. Attempt was associated with 1.44–1.61 odds of later alcohol, nicotine and cannabis dependence, even after accounting for covariates. Evidence for early substance use being related to subsequent onset of ideation or attempt was limited. Several sex and race differences emerged. Limitations The sample was ascertained for family history of alcoholism; not all participants had been followed up allowing for censored observations; reporting bias. Conclusion Suicide attempts are associated with increased likelihood of onset of substance dependence.

KW - Alcohol

KW - Attempt

KW - Cannabis

KW - COGA

KW - Ideation

KW - Nicotine

KW - Suicide

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