Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer

Saroj Vadhan-Raj, Claire F. Verschraegen, Carlos Bueso-Ramos, Hal E. Broxmeyer, Andrzej P. Kudelka, Ralph S. Freedman, Creighton L. Edwards, David Gershenson, Dennie Jones, Mark Ashby, John J. Kavanagh

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Abstract

Background: Thrombocytopenia is a significant problem in the treatment of cancer. Objective: To assess the clinical safety of therapy with recombinant human thrombopoietin (rhTPO) and its ability to ameliorate chemotherapy-induced severe thrombocytopenia. Design: Phase 1/11 clinical cohort study. Setting: The University of Texas M.D. Anderson Cancer Center, Houston, Texas. Patients: 29 patients with gynecologic cancer. Intervention: Recombinant human thrombopoietin was given before chemotherapy and after a second cycle of carboplatin therapy. Measurements: Peripheral blood counts and platelet transfusions. Results: Administration of rhTPO after chemotherapy significantly reduced the degree and duration of thrombocytopenia and enhanced platelet recovery. In patients who received the optimal biological dose of rhTPO (1.2 μg/kg of body weight) in cycle 2 (carboplatin plus rhTPO), the mean platelet count nadir was higher (44 x 109 cells/L and 20 x 109 cells/L;P = 0.002) and the duration of thrombocytopenia was shorter (days with a platelet count <20 x 109 cells/L, 1 and 4 [P = 0.002]; days with a platelet count <50 x 109 cells/L, 4 and 7 [P = 0.006]) than in cycle 1 (carboplatin only). The need for platelet transfusion in this group was reduced from 75% of patients in cycle 1 to 25% of patients in cycle 2 (P 0.013). Conclusions: Therapy with rhTPO seems to be safe and may attenuate chemotherapy-induced severe thrombocytopenia and reduce the need for platelet transfusions.

Original languageEnglish (US)
Pages (from-to)364-368
Number of pages5
JournalAnnals of internal medicine
Volume132
Issue number5
DOIs
StatePublished - Mar 7 2000

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ASJC Scopus subject areas

  • Internal Medicine

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Vadhan-Raj, S., Verschraegen, C. F., Bueso-Ramos, C., Broxmeyer, H. E., Kudelka, A. P., Freedman, R. S., Edwards, C. L., Gershenson, D., Jones, D., Ashby, M., & Kavanagh, J. J. (2000). Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer. Annals of internal medicine, 132(5), 364-368. https://doi.org/10.7326/0003-4819-132-5-200003070-00005