Recovery time course in contractile function of fast and slow skeletal muscle after hindlimb immobilization

Frank Witzmann, D. H. Kim, R. H. Fitts

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Abstract

Contractile properties were evaluated in rats remobilized after 6 wk of hindlimb casting to evaluate the regenerative capacity of fast and slow skeletal muscles. Contractile parameters were determined in vitro (22°C) in the type I soleus (SOL), type IIA and IIB extensor digitorum longus (EDL), and the type IIB superficial vastus lateralis (SVL). Immobilization (IM) shortened the SOL isometric twitch duration after which contraction time and half-relaxation time required 4 and 7 days to recover, respectively. In contrast, IM prolonged the twitch in the EDL and SVL and recovery required 14 and 7 days, respectively. Peak tetanic tension (g/cm2) fell in the SOL and EDL with IM and full recovery required 28 days. In this regard, the SVL remained unaltered. Rates of tension development and decline remained essentially unaltered in the fast muscles after IM but fell in the SOL, requiring 14 days to fully recover. Maximal shortening velocity, which had been elevated in all three muscles by IM, recovered rapidly. The present results demonstrate that both fast and slow muscle have the ability to completely recover from 6 weeks of IM.

Original languageEnglish (US)
Pages (from-to)677-682
Number of pages6
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume52
Issue number3
StatePublished - 1982
Externally publishedYes

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Hindlimb Suspension
Immobilization
Skeletal Muscle
Quadriceps Muscle
Muscles
Hindlimb

ASJC Scopus subject areas

  • Endocrinology
  • Physiology

Cite this

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abstract = "Contractile properties were evaluated in rats remobilized after 6 wk of hindlimb casting to evaluate the regenerative capacity of fast and slow skeletal muscles. Contractile parameters were determined in vitro (22°C) in the type I soleus (SOL), type IIA and IIB extensor digitorum longus (EDL), and the type IIB superficial vastus lateralis (SVL). Immobilization (IM) shortened the SOL isometric twitch duration after which contraction time and half-relaxation time required 4 and 7 days to recover, respectively. In contrast, IM prolonged the twitch in the EDL and SVL and recovery required 14 and 7 days, respectively. Peak tetanic tension (g/cm2) fell in the SOL and EDL with IM and full recovery required 28 days. In this regard, the SVL remained unaltered. Rates of tension development and decline remained essentially unaltered in the fast muscles after IM but fell in the SOL, requiring 14 days to fully recover. Maximal shortening velocity, which had been elevated in all three muscles by IM, recovered rapidly. The present results demonstrate that both fast and slow muscle have the ability to completely recover from 6 weeks of IM.",
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AU - Kim, D. H.

AU - Fitts, R. H.

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N2 - Contractile properties were evaluated in rats remobilized after 6 wk of hindlimb casting to evaluate the regenerative capacity of fast and slow skeletal muscles. Contractile parameters were determined in vitro (22°C) in the type I soleus (SOL), type IIA and IIB extensor digitorum longus (EDL), and the type IIB superficial vastus lateralis (SVL). Immobilization (IM) shortened the SOL isometric twitch duration after which contraction time and half-relaxation time required 4 and 7 days to recover, respectively. In contrast, IM prolonged the twitch in the EDL and SVL and recovery required 14 and 7 days, respectively. Peak tetanic tension (g/cm2) fell in the SOL and EDL with IM and full recovery required 28 days. In this regard, the SVL remained unaltered. Rates of tension development and decline remained essentially unaltered in the fast muscles after IM but fell in the SOL, requiring 14 days to fully recover. Maximal shortening velocity, which had been elevated in all three muscles by IM, recovered rapidly. The present results demonstrate that both fast and slow muscle have the ability to completely recover from 6 weeks of IM.

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