Recruiting minorities into clinical trials toward a participant-friendly system

G. Marie Swanson, Amy J. Ward

Research output: Contribution to journalArticle

425 Citations (Scopus)

Abstract

The purpose of this review is to describe the state of the art in recruiting participants for clinical trials designed to test new methods of treatment or disease prevention. The ultimate objective of this review is to provide a summary of key issues in recruiting diverse populations into clinical trials, particularly ethnic and racial minorities. An overview of general issues related to clinical trial participation is followed by a detailed discussion of specific issues that must be addressed by investigators as they recruit minority populations for clinical trial. To date, the majority of clinical trials have included a limited segment of the U.S. population: middle-class, married white males. These trials have faced many problems in their efforts to recruit participants, including barriers to physician participation, barriers to subject participation, barriers to planning and implementing effective recruitment strategies, and costs of the recruitment phase of clinical trials. Following this general introduction is a discussion of the definition of diverse populations. The first step investigators must take as they prepare to recruit study participants is to develop a relevant definition of the subject populations. A detailed review of investigators' experiences in recruiting minorities into clinical trials is presented, including barriers to minority recruitment, barriers inherent in study design, researcher bias, barriers to minority physician participation, as well as strategies for minority recruitment, modifications of study design, and cost issues. Formal evaluation of recruitment strategies has been limited. Most investigators present descriptive reports of their experience in recruiting diverse populations into clinical trials. Research into the issues presented and rigorous testing of specific strategies is needed. A series of steps that are essential to effective clinical trials recruitment of diverse populations is presented.

Original languageEnglish (US)
Pages (from-to)1747-1759
Number of pages13
JournalJournal of the National Cancer Institute
Volume87
Issue number23
DOIs
StatePublished - Dec 6 1995
Externally publishedYes

Fingerprint

Clinical Trials
Research Personnel
Population
Costs
Planning
Testing
Physicians
Recruiting
Clinical trials
Minorities
Costs and Cost Analysis
Social Class
Series
Strategy
Participation
Evaluation
Research
Review

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Oncology
  • Cancer Research

Cite this

Recruiting minorities into clinical trials toward a participant-friendly system. / Swanson, G. Marie; Ward, Amy J.

In: Journal of the National Cancer Institute, Vol. 87, No. 23, 06.12.1995, p. 1747-1759.

Research output: Contribution to journalArticle

Swanson, G. Marie ; Ward, Amy J. / Recruiting minorities into clinical trials toward a participant-friendly system. In: Journal of the National Cancer Institute. 1995 ; Vol. 87, No. 23. pp. 1747-1759.
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