Recurrence and resistance patterns of herpes simplex virus following cessation of ≥6 years of chronic suppression with acyclovir

Kenneth Fife, Clyde S. Crumpacker, Gregory J. Mertz, Edgar L. Hill, Gloria S. Boone

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Abstract

Questions have arisen regarding the clinical outcome and the possible selection of resistant virus when patients with genital herpes discontinue prolonged chronic acyclovir; 239 immunocompetent patients with a history of frequently recurring genital herpes who stopped successful suppressive therapy after 6 years were studied. Of the patients, 85.8% had at least one recurrence and 75% had at least two recurrences in the subsequent year (median time to first and second recurrence, 68 and 180 days, respectively). Herpes simplex virus isolates recovered from these patients had a median acyclovir sensitivity of 0.79 μg/mL and 4 (3.5%) were resistant (≥3 μg/mL). These values are comparable to those of pretherapy isolates and to reported values of isolates from acyclovir-naive patients. Also, paired pre- and posttherapy isolates from 13 patients showed no trend toward development of resistance. Thus, even after 6 years of acyclovir suppression, most patients continue to have recurrences, but the selection of resistant virus has not been observed.

Original languageEnglish
Pages (from-to)1338-1341
Number of pages4
JournalJournal of Infectious Diseases
Volume169
Issue number6
StatePublished - Jun 1994

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Acyclovir
Simplexvirus
Recurrence
Herpes Genitalis
Viruses

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Recurrence and resistance patterns of herpes simplex virus following cessation of ≥6 years of chronic suppression with acyclovir. / Fife, Kenneth; Crumpacker, Clyde S.; Mertz, Gregory J.; Hill, Edgar L.; Boone, Gloria S.

In: Journal of Infectious Diseases, Vol. 169, No. 6, 06.1994, p. 1338-1341.

Research output: Contribution to journalArticle

Fife, Kenneth ; Crumpacker, Clyde S. ; Mertz, Gregory J. ; Hill, Edgar L. ; Boone, Gloria S. / Recurrence and resistance patterns of herpes simplex virus following cessation of ≥6 years of chronic suppression with acyclovir. In: Journal of Infectious Diseases. 1994 ; Vol. 169, No. 6. pp. 1338-1341.
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