Recurrence and resistance patterns of herpes simplex virus following cessation of 6 years of chronic suppression with acyclovir

Acyclovir Study Group

Research output: Contribution to journalArticle

149 Scopus citations

Abstract

Questions have arisen regarding the clinical outcome and the possible selection of resistant virus when patients with genital herpes discontinue prolonged chronic acyclovir; 239 immunocompetent patients with a history of frequently recurring genital herpes who stopped successful suppressive therapy after 6 years were studied. Of the patients, 85.8% had at least one recurrence and 75% had at least two recurrences in the subsequent year (median time to first and second recurrence, 68 and 180 days, respectively). Herpes simplex virus isolates recovered from these patients had a median acyclovir sensitivity of 0.79 μg/mL and 4 (3.5%) were resistant (≥3 μg/mL). These values are comparable to those of pretherapy isolates and to reported values of isolates from acyclovir-naive patients. Also, paired pre- and posttherapy isolates from 13 patients showed no trend toward development of resistance. Thus, even after 6 years of acyclovir suppression, most patients continue to have recurrences, but the selection of resistant virus has not been observed.

Original languageEnglish (US)
Pages (from-to)1338-1341
Number of pages4
JournalJournal of Infectious Diseases
Volume169
Issue number6
DOIs
StatePublished - Jun 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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